CAS: 612503-08-9; 2-Methyl-10H-Benzo[b]Thieno[2,3-E][1,4]Diazepin-4-Amine

上下游产品

4-amino-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine hydr°Chloride 2-amino-5-methylthiophene-3-carbonitrile ortho-nitrofluorobenzene 2-(2-nitroanilino)-5-methylthiophene-3-carbonitrile (S)-2-methyl-10-(3-(4-phenyl-butyl)-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene (S)-2-methyl-10-(3-(3-phenyl-propyl)-piperazin-1-yl)-4H-3-thia-4,9-diaza-benzo[f]azulene zyprexa N-desmethyl olanzapine

📜1-氟-2-硝基苯置于盐酸,氢氧化钾体系中,用 二甲基亚砜,乙酸乙酯,异丙醇 作为反应溶剂,化学反应生成 2-甲基-10H-苯并[b]噻吩并[2,3-E][1,4]二氮杂革-4-胺
参考文献:Antibodies To Olanzapine Haptens And Use Thereof
标题:Antibodies To Olanzapine Haptens And Use Thereof
摘要:揭示了一种与奥氮平结合的抗体,可用于在样本中检测奥氮平,例如在竞争性免疫分析方法中使用.该抗体可用于侧向流动测定装置,用于奥氮平的现场检测,包括在单个侧向流动测定装置中多重检测阿立哌唑,奥氮平,奎硫平和利培酮.

专利信息

专利号:WO-2005070939-A1
优先权日:2004-01-27
标 题:Synthesis of olanzapine and intermediates thereof
发明人：KELTJENS ROLF; PETERS THEODORUS HENDRICUS ANT
权利人:SYNTHON BV; KELTJENS ROLF; PETERS THEODORUS HENDRICUS ANT
摘要:Olanzapine and salts thereof are made by a process that utilizes an N-formyl olanzapine intermediate of formula (4) or a salt thereof.

专利号:US-9303041-B2
优先权日:2012-08-21
标题 :Haptens of olanzapine
发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

专利号:US-7863442-B2
优先权日:2007-06-22
标题:Processes for the synthesis of olanzapine
发明人：KOTHAKONDA KIRAN KUMAR; CHE DAQING; GUNTOORI BHASKAR REDDY
权利人:APOTEX PHARMACHEM INC
摘要:There is provided a process for the preparation of olanzapine comprising:n i) reacting 4-amino-2-methyl-10H-thieno-[2,3-b][1,5]benzodiazepine and N-methylpiperazine in a C 1 to C 4 alcoholic solvent or mixture thereof at suitable temperature and for a suitable time, ii) cooling the reaction mixture, and iii) isolating the precipitated olanzapine.

专利号:US-9751851-B2
优先权日:2013-09-20
标 题:Molecules and compositions that inhibit gram negative bacteria and their uses
发明人：BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; CONRAD-MILLER LAURA C; O'LOUGHLIN COLLEEN T
权利人:UNIV PRINCETON; BASSLER BONNIE L; SEMMELHACK MARTIN F; DRESCHER KNUT; SIRYAPORN ALBERT; MILLER LAURA C; O'LOUGHLIN COLLEEN T
摘要:Antivirulence strategies to combat Pseudomonas aeruginosa , are described. One strategy encompasses synthesis of a series of compounds that inhibit the production of pyocyanin, a redox-active virulence factor produced by this pathogen. A related strategy encompasses synthesis of compounds that inhibit the two P. aeruginosa quorum-sensing receptors, LasR and RhlR, inhibit production of pyocyanin, and inhibit biofilm formation.

专利号:US-2005267099-A1
优先权日:2004-01-27
标题:Synthesis of olanzapine and intermediates thereof

专利号:CA-2558654-A1
优先权日:2004-03-18
标 题:Synthesis of 2-methyl-4-(4-methyl-1-piperazinyl)-10h-thieno[2, 3-b][1,5]benzodiazepine and salts thereof