CAS: 586-30-1; 3-Hydroxy-4-Methylbenzoic Acid

该化合物是一种芳香的碳酸,其特点是一种氢氧化物组和附于苯酸结构的甲基组,分子式为C8H8O3,其特点是苯丙基氢基,该组有助于其酸性和氢联结潜力.该化合物一般是白色至白晶状固体,在乙醇和丙酮等有机溶剂中溶解,但在水中溶解性有限.该化合物具有苯丙酸化合物的典型特性,包括抗氧化剂活动以及药物和化妆品的潜在应用.其存在时,可产生多种化学反应,有助于有机合成.此外,该化合物的结构特征可能会影响其在生物系统中的行为,可能影响其再活动及其与其他分子的相互作用.

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欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

CAS号62454-72-2 4-methyl-3-sulf... | CAS号3816-66-8 3-羟基-4-甲基苯腈 | CAS号99-94-5 对甲基苯甲酸 | CAS号5162-82-3 3-氯-4-甲基苯甲酸 | CAS号7697-26-9 3-溴-4-甲基苯甲酸 | CAS号7151-68-0 3-甲氧基-4-甲基苯甲酸 | CAS号939-79-7 4-甲基-3-硝基氰苯 | CAS号60710-80-7 3-氨基-4-甲基苯腈 | CAS号36138-76-8 5-溴-2-甲基苯酚 | CAS号3556-83-0 3-甲氧基-4-甲基苯甲酸甲 | CAS号57295-30-4 3-羟基-4-甲基苯甲醛 | CAS号3556-86-3 3-羟基-4-甲基苯甲酸甲酯 | CAS号4670-56-8 4-甲基水杨酸甲酯 | CAS号64829-31-8 3-甲氧基-4-甲基苯乙腈 | CAS号7151-68-0 3-甲氧基-4-甲基苯甲酸 | CAS号33414-48-1 3-HYDROXY-4-MET... | CAS号17477-46-2 3-乙酰氧基-4-甲基苯甲酸 | CAS号24973-22-6 3-甲氧基-4-甲基苯甲醛 | CAS号95-48-7 邻甲酚

合成工艺路线路线简述

    Thiocarvacrol置于碘,硝酸,Potassium Carbonate体系中,化学反应生成 3-羟基-4-甲基苯甲酸
    参考文献:Flesch,Chemische Berichte,1873,Vol. 6,P. 478
    标题:Flesch,Chemische Berichte,1873,Vol. 6,P. 478

    海关参考信息

    专利信息


    专利号:US-6180830-B1
    优先权日:1995-11-08
    标题 :Method for preparing a bimetallic ruthenium/tin catalyst and a process for the synthesis of aldehydes
    发明人:JACQUOT ROLAND
    权利人:RHODIA CHIMIE SA
    摘要:The present invention relates to a new process for the preparation of a bimetallic ruthenium/tin catalyst. The process for the preparation of a bimetallic ruthenium/tin catalyst according to the invention is characterised by the fact that it consists in carrying out the reduction of a ruthenium complex having an electrovalency of -4 and a coordination number of 6, the ligands being either a halogen atom or an anion or a tin halide. The catalyst is further employed for the preparation of aldehydes by reduction, in the vapor phase, of carboxylic acids, esters and anhydrides.

    专利号:US-7253324-B1
    优先权日:2007-01-23
    标 题:Process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkylethers
    发明人:MAJEED MUHAMMED; THOMAS SAMUEL MANOHARAN; NAGABHUSHANAM KALYANAM; BALAKRISHNAN SIVAPRAKASH KURUM; PRAKASH SUBBALAKSHMI
    权利人:SAMI LABS LTD
    摘要:Alkoxy aromatic compounds are conveniently dealkylated to the corresponding phenolic compounds by treatment with aluminum chloride/N,N-dimethyl aniline complex. Aromatic poly O-demethylation is a unique feature of this invention. This process is applicable to the manufacture of polyphenols such as Resveratrol, Oxyresveratrol, Gnetol.

    专利号:US-2004110228-A1
    优先权日:2002-04-01
    标 题:Combinatorial organic synthesis of unique biologically active compounds
    发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
    摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

    专利号:US-6150403-A
    优先权日:1997-10-14
    标 题 :Topical compositions for regulating the oily/shiny appearance of skin
    发明人:BIEDERMANN KIMBERLY A; SCHUBERT HARRY L; PARRAN JR JOHN J
    权利人:PROCTER & GAMBLE
    摘要:The present invention relates to methods for inhibiting sebaceous gland activity in mammalian skin comprising administration of a topical composition comprising dehydroacetic acid or pharmaceutically acceptable salts thereof, and a dermatologically-acceptable carrier. The present invention also relates to methods and topical compositions further comprising agents which regulate the oily and/or shiny appearance of skin, and agents which treat acne and related skin disorders in mammalian skin and scalp. Methods of reducing sebum synthesis with the use of dehydroacetic acid, methods of regulating the oily and/or shiny appearance of skin, and methods of treating acne and other skin disorders are also encompassed by the present invention.

    专利号:WO-2008091379-A1
    优先权日:2007-01-23
    标题 :A process for the synthesis of biologically active oxygenated compounds by dealkylation of the corresponding alkyllethers

    专利号:EP-1836163-B1
    优先权日:2004-12-23
    标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
    发明人:BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
    权利人:NOVARTIS AG
    摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.
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    合成参考文献


    摘要:D. Peltier, Bull. Soc. Chim. Fr. 1958, 994. Values also quoted from D. Peltier, Thesis, Rennes, (1956); C. R. Acad. Sci., Ser. C 243, 2086 (1956); 244, 2811 (1957); 245, 436 (1957).
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