专利号:US-6818777-B2 优先权日:2000-12-07 标 题:Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate 发明人:FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI 权利人:JAPAN SCIENCE & TECH AGENCY 摘要:Intermediates A, which are important in the whole synthesis of vindoline; and a method of synthesizing intermediates respectively represented by the general formulae B and C. By the method, the target intermediates are effectively synthesized with satisfactory reproducibility. This synthesis method is especially suitable for mass production. General formula A General formula B General formula C.
专利号:US-2007208164-A1 优先权日:2006-02-27 标题:Methods of synthesizing radiolabeled 3-cyano[14C]quinolines 发明人:OLSZEWSKI JOHN D; MAY MICHAEL K; BERGER DAN M 权利人:WYETH CORP 摘要:The present invention is directed to radiolabeled 3-cyanoquinolines of the formula: n n nand methods of synthesizing the same, wherein G 1 , G 2 R 1 , R 4 , Z, X, and n are as defined herein. n nThe present invention is also directed to a radiolabeled intermediate compounds of formula (VII): n n nwherein PG, G 1 , R 1 , R 4 , R 10 , and R 11 are as defined herein, and synthesis of the same.
专利号:US-4267234-A 优先权日:1978-03-17 标题:Polyglutaraldehyde synthesis and protein bonding substrates 发明人:REMBAUM ALAN 权利人:CALIFORNIA INST OF TECHN 摘要:Polyglutaraldehyde (PGL) is polymerized in aqueous base or in aqueous highly polar solvent basic media to prepare powders, castable films or coatings for substrates such as amine substituted microbeads. PGL microspheres can be prepared by suspension polymerization in presence of a surfactant or by precipitating PGL from solution containing surfactant. Magnetic PGL microspheres are formed by suspension polymerization in the presence of magnetic particles such as iron oxide. Polyglutaraldehyde can be converted to a fluorescent polymer by reaction with m-aminophenol or other reagent. Proteins can be readily covalently bound to the polyglutaraldehyde.
专利号:US-4369226-A 优先权日:1979-03-19 标 题:Polyglutaraldehyde synthesis and protein bonding substrates 发明人:REMBAUM ALAN 权利人:CALIFORNIA INST OF TECHN 摘要:Polyglutaraldehyde (PGL) is polymerized in aqueous base or in aqueous highly polar solvent basic media to prepare powders, castable films or coatings for substrates such as amine substituted microbeads. PGL microspheres can be prepared by suspension polymerization in presence of a surfactant or by precipitating PGL from solution containing surfactant. Magnetic PGL microspheres are formed by suspension polymerization in the presence of magnetic particles such as iron oxide. Polyglutaraldehyde can be converted to a fluorescent polymer by reaction with m-aminophenol or other reagent. Proteins can be readily covalently bound to the polyglutaraldehyde.
专利号:US-4622400-A 优先权日:1983-12-29 标 题:Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes 发明人:HAMMOND PETER R 权利人:US ENERGY 摘要:Methods are provided for making certain m-aminophenols using a sulfonation/alkali fusion procedure. The aminophenols are key intermediates in the synthesis of dyes, particularly efficient, stable dyes for laser application. Preparations of some rhodamine and phenoxazone dyes from the m-aminophenols are described.
专利号:US-2004034217-A1 优先权日:2000-12-07 标题 :Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate
参考文献:10.1002/anie.200503209 摘要:Kwon OH, Lee YS, Yoo BK, Jang DJ. Excited-state triple proton transfer of 7-hydroxyquinoline along a hydrogen-bonded alcohol chain: vibrationally assisted proton tunneling. Angew Chem Int Ed Engl. 2006 Jan 09;45(3):415–9. doi: 10.1002/anie.200503209.