CAS: 580-20-1; Quinolin-7-Ol

该化合物是一种有机化合物,其特征为在7点方位上有一个有氢氧基化合物的quinoline结构,其表面是黄色至褐色的灰色固体,以其芳香特性而著称;该化合物的分子分子式为C9H7NO,分子重量约为161.16克/摩尔.7-Hydroxyquinline在水中表现出中等溶解性,在乙醇和丙酮等有机溶剂中更加溶解.它主要用于各种用途,包括作为分析化学的试剂,合成药物的前体,以及协调化学的悬浮剂,因为它能够形成金属离子的复合体.此外,已经对其潜在的生物活动,包括抗微生物和抗氧化毒特性进行了7-氢基线的研究.然而,处理这一化合物需要谨慎,因为如果注入或吸入丙酮,可能会对健康造成危害.在实验室环境中与该物质合作时,应当遵守适当的安全措施.

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合成工艺路线路线简述

    📜7-羟基-1,2,3,4-四氢喹啉置于sodium Carbonate体系中,用 乙酸乙酯 作为反应溶剂,化学反应 48.0H,以14%的收率获得产物7-羟基喹啉
    参考文献:在空气下使用氧化石墨烯作为多功能无金属催化剂对氮杂环进行脱氢
    标题:在空气下使用氧化石墨烯作为多功能无金属催化剂对氮杂环进行脱氢
    摘要:氧化石墨烯(go)已开发为一种廉价,环保,无金属的碳催化剂,可用于氮杂环的脱氢.有价值的化合物,例如喹啉,3,4-二氢异喹啉,喹唑啉和吲哚衍生物已成功用作底物.对具有不同共轭体系的各种含氧分子的研究表明,Go片中的含氧基团和较大的π共轭体系对于该反应都是必不可少的.
    DOI:10.1002/adsc.201700178

    海关参考信息

    专利信息


    专利号:US-6818777-B2
    优先权日:2000-12-07
    标 题:Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate
    发明人:FUKUYAMA TOHRU; TOKUYAMA HIDETOSHI
    权利人:JAPAN SCIENCE & TECH AGENCY
    摘要:Intermediates A, which are important in the whole synthesis of vindoline; and a method of synthesizing intermediates respectively represented by the general formulae B and C. By the method, the target intermediates are effectively synthesized with satisfactory reproducibility. This synthesis method is especially suitable for mass production. General formula A General formula B General formula C.

    专利号:US-2007208164-A1
    优先权日:2006-02-27
    标题:Methods of synthesizing radiolabeled 3-cyano[14C]quinolines
    发明人:OLSZEWSKI JOHN D; MAY MICHAEL K; BERGER DAN M
    权利人:WYETH CORP
    摘要:The present invention is directed to radiolabeled 3-cyanoquinolines of the formula: n n nand methods of synthesizing the same, wherein G 1 , G 2 R 1 , R 4 , Z, X, and n are as defined herein. n nThe present invention is also directed to a radiolabeled intermediate compounds of formula (VII): n n nwherein PG, G 1 , R 1 , R 4 , R 10 , and R 11 are as defined herein, and synthesis of the same.

    专利号:US-4267234-A
    优先权日:1978-03-17
    标题:Polyglutaraldehyde synthesis and protein bonding substrates
    发明人:REMBAUM ALAN
    权利人:CALIFORNIA INST OF TECHN
    摘要:Polyglutaraldehyde (PGL) is polymerized in aqueous base or in aqueous highly polar solvent basic media to prepare powders, castable films or coatings for substrates such as amine substituted microbeads. PGL microspheres can be prepared by suspension polymerization in presence of a surfactant or by precipitating PGL from solution containing surfactant. Magnetic PGL microspheres are formed by suspension polymerization in the presence of magnetic particles such as iron oxide. Polyglutaraldehyde can be converted to a fluorescent polymer by reaction with m-aminophenol or other reagent. Proteins can be readily covalently bound to the polyglutaraldehyde.

    专利号:US-4369226-A
    优先权日:1979-03-19
    标 题:Polyglutaraldehyde synthesis and protein bonding substrates
    发明人:REMBAUM ALAN
    权利人:CALIFORNIA INST OF TECHN
    摘要:Polyglutaraldehyde (PGL) is polymerized in aqueous base or in aqueous highly polar solvent basic media to prepare powders, castable films or coatings for substrates such as amine substituted microbeads. PGL microspheres can be prepared by suspension polymerization in presence of a surfactant or by precipitating PGL from solution containing surfactant. Magnetic PGL microspheres are formed by suspension polymerization in the presence of magnetic particles such as iron oxide. Polyglutaraldehyde can be converted to a fluorescent polymer by reaction with m-aminophenol or other reagent. Proteins can be readily covalently bound to the polyglutaraldehyde.

    专利号:US-4622400-A
    优先权日:1983-12-29
    标 题:Preparation of certain m-aminophenols and the use thereof for preparation of laser dyes
    发明人:HAMMOND PETER R
    权利人:US ENERGY
    摘要:Methods are provided for making certain m-aminophenols using a sulfonation/alkali fusion procedure. The aminophenols are key intermediates in the synthesis of dyes, particularly efficient, stable dyes for laser application. Preparations of some rhodamine and phenoxazone dyes from the m-aminophenols are described.

    专利号:US-2004034217-A1
    优先权日:2000-12-07
    标题 :Intermediates for synthesis of vinblastine compound and method for synthesizing the intermediate

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    合成参考文献


    参考文献:10.1002/anie.200503209
    摘要:Kwon OH, Lee YS, Yoo BK, Jang DJ. Excited-state triple proton transfer of 7-hydroxyquinoline along a hydrogen-bonded alcohol chain: vibrationally assisted proton tunneling. Angew Chem Int Ed Engl. 2006 Jan 09;45(3):415–9. doi: 10.1002/anie.200503209.
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