CAS: 5793-88-4; Calcium (2R,3S,4S,5S)-2,3,4,5-Tetrahydroxyhexanedioate

📜Calcium Gluconate 在 Sodium Hypochlorite,2,2,6,6-四甲基哌啶氧化物,水,Sodium Bromide体系中,反应 2.0H,以82.8%的收率获得calcium D-Glucarate
参考文献:葡萄糖二酸钙的制备方法
标题:葡萄糖二酸钙的制备方法
摘要:本发明属于制药领域,具体涉及一种葡萄糖二酸钙的制备方法.所述的葡萄糖二酸钙的制备方法,将d‑葡萄糖酸盐加入反应容器中,降温至‑30‑50°C,加入催化剂,溶剂和氧化剂,进行催化氧化反应,得到葡萄糖二酸盐溶液;将葡萄糖二酸盐溶液与钙盐进行反应,得葡萄糖二酸钙;其中,所述的d‑葡萄糖酸盐为d‑葡萄糖酸钠,D‑葡萄糖酸锂,D‑葡萄糖酸钾,D‑葡萄糖酸钙,D‑葡萄糖酸镁或d‑葡萄糖酸锌.本发明采用d‑葡萄糖酸盐为原料,氧化剂用量少,操作简单,收率高,产品符合国内外药用辅料的质量要求,生产成本低,工业三废少,适合工业生产,对环境无污染.

专利信息

专利号:US-2006084800-A1
优先权日:2004-06-30
标 题 :Synthesis of aldonolactones, aldarolactones, and aldarodilactones using azeotropic distillation
发明人：CHENAULT HENRY K
权利人:CHENAULT HENRY K
摘要:Processes for making lactones and dilactones from aldaric acids, aldonic acids, and their corresponding salts by dehydrative cyclization and azeotropic distillation. The processes can be carried out in the presence of water because water is removed by azeotropic distillation.

专利号:WO-2006005071-A1
优先权日:2004-06-30
标题:Synthesis of aldonolactones, aldarolactones, and aldarodilactones using azeotrophic distillation
发明人：CHENAULT H KEITH
权利人:DU PONT; CHENAULT H KEITH
摘要:Processes for making lactones and dilactones from aldaric acids, aldonic acids, and their corresponding salts by dehydrative cyclization and azeotropic distillation. The processes can be carried out in the presence of water because water is removed by azeotropic distillation.

专利号:US-7550510-B2
优先权日:2001-07-06
标 题 :Solid phase synthesis of arylretinamides
发明人：CURLEY JR ROBERT W; MERSHON SERENA M; BARNETT DEREK W; CLAGETT-DAME MARGARET; CHAPMAN JASON S
权利人:WISCONSIN ALUMNI RES FOUND
摘要:A solid phase synthetic method for preparing arylretinamides is provided. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixture; and stirring the resulting mixture for a time and at a temperature sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. Also provided, are select arylretinamides that can be prepared by the present method, and methods of using such arylretinamides to induce apoptosis in cancer cells.

专利号:US-2004102650-A1
优先权日:2001-07-06
标 题:Solid phase synthesis of arylretinamides

专利号:US-2006084817-A1
优先权日:2004-06-30
标 题 :Synthesis of aldonolactones, aldarolactones, and aldarodilactones using gas sparging
发明人：CHENAULT HENRY K
权利人:CHENAULT HENRY K
摘要:Aldaric acids, aldonic acids, and their corresponding salts are cyclized to the corresponding lactone or dilactone using gas sparging to remove water.

专利号:WO-2006005070-A1
优先权日:2004-06-30
标题 :Synthesis of aldonolactones, aldarolactones, and aldarodilactones using gas sparging