2-Isopropyl-3-Methyl-5-Oxo-2,5-Dihydro-Isoxazole-4-Carboxylic Acid Ethyl Ester置于盐酸,溶剂黄146体系中,用 水 作为反应溶剂,以96%的收率获得产物n-异丙基羟胺 参考文献:An Efficient Synthesis Of N-Monoalkylated Hydroxylamines 标题:An Efficient Synthesis Of N-Monoalkylated Hydroxylamines 摘要: DOI:10.1016/s0040-4039(00)96265-8
专利信息
专利号:US-7807764-B2 优先权日:2003-08-27 标 题:Composition and process for the controlled synthesis of block copolymers 发明人:WERMTER HENDRIK; SIMON DIRK; PFAENDNER RUDOLF 权利人:CIBA SC HOLDING AG 摘要:The present invention relates to a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) at least one hydroxylamine of high molecular weight, preferably a long chain alkyl substituted hydroxylamine. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers, and the use of high molecular weight hydroxylamines for controlled polymerization.
专利号:US-2004110228-A1 优先权日:2002-04-01 标 题:Combinatorial organic synthesis of unique biologically active compounds 发明人:MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M 摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.
专利号:US-7041761-B2 优先权日:2002-08-16 标题:Functionalized monomers for synthesis of rubbery polymers 发明人:HALASA ADEL FARHAN; HSU WEN-LIANG 权利人:GOODYEAR TIRE & RUBBER 摘要:The present invention relates to a process for synthesizing a rubbery polymer that comprises copolymerizing at least one conjugated diolefin monomer and at least one functionalized monomer in an organic solvent at a temperature which is within the range of 0° C. to about 150° C., wherein the polymerization is initiated with an anionic initiator, wherein the polymerization is conducted in the absence of conventional polar modifiers, and wherein the functionalized monomer is of the structural formula: n nwherein the R′ groups in repeat units and in different repeat units can be the same or different and represent hydrogen atoms or alkyl groups containing from 1 to about 4 carbon atoms, wherein x represents an integer from 1 to about 10, and wherein the R groups in repeat units and in different repeat units can be the same or different and represent alkyl groups containing from 1 to about 10 carbon atoms or alkoxy groups containing from 1 to about 10 carbon atoms.
专利号:US-2005192265-A1 优先权日:2003-03-20 标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 发明人:THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
专利号:WO-2024256666-A1 优先权日:2023-06-16 标 题:Production of synthesis gas by partial oxidation of a hydrocarbon stream containing plastic liquefaction oil 发明人:ADAM CINDY; CHOFFAT ALEXANDRINE; MINOUX DELPHINE; VAN LOOK EMMANUEL; BRETON CHRISTOPHE 权利人:TOTALENERGIES ONETECH 摘要:The invention relates to a process for the production of synthesis gas by partial oxidation from a hydrocarbon stream containing plastic liquefaction oil, comprising: a) providing a composition stabilized against premature polymerization comprising: 1) a hydrocarbon stream containing at least 2 wt% of plastic liquefaction oil which is containing contaminants, the remaining part of said hydrocarbon stream being a diluent, 2) at least one additive capable to reduce gums formation or buildup, 3) optionally at least one additive which is a dispersant agent, b) an optional purification step to trap silicon and/or metals and/or phosphorous and/or halogenates over at least one trap to obtain a purified composition, c) gasifying by partial oxidation the stabilized composition provided in step (a), or the purified composition provided in step (b), in a partial oxidation gasification unit to produce synthesis gas comprising at least dihydrogen, carbon monoxide, and carbon dioxide.
专利号:US-6906056-B2 优先权日:1998-06-22 标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds 发明人:THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J 权利人:LILLY CO ELI 摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要:Merino, P., Science of Synthesis Knowledge Updates, (2010) 4, 354. 摘要:Wessjohann, L. A.; Kaluđerović, G. N.; Neves Filho, R. A. W.; Morejon, M. C.; Lemanski, G.; Ziegler, T., Science of Synthesis: Multicomponent Reactions, (2013) 1, 439.