CAS: 491-71-4; 5,7-Dihydroxy-2-(4-Hydroxy-3-Methoxyphenyl)-4H-Chromen-4-One

上下游产品

木犀草素-5,3'-二甲醚 7,4′-Dihydroxy-5,3′-Dimethoxyflavone 62346-14-9
木犀草素 2-(3,4-Dihydroxy-Phenyl)-5,7-Dihydroxy-Chromen-4-On 491-70-3
Chrysoeriol-4′-O-α-L-Rhamnopyranoside
柯伊利素-7-O-葡萄糖苷 Chrysoeriol 7-O-Glucoside 19993-32-9
Chrysoeriol-7-O-β-D-Glucopyranosyl-4′-O-α-L-Rhamnopyranoside
Chrysoeriol-4'-O-α-L-Rhamnopyranosyl-(1->2)-β-D-Galactopyranosyl-(1->6)-β-D-Glucopyranoside
5,7,4'-Trihydroxy-3'-Methoxyflavone-4'-O-α-L-Rhamnopyranosyl-(1→4)-O-α-L-Arabino-Pyranosyl-(1→3)-O-β-D-Galactopyranoside
Chrysoeriol 7-(2''-O-β-D-Allopyranosyl)-β-D-Glucopyranoside
Crotonoylthermopsoside 123656-61-1
Chrysoeriol-7-O-(2″-O-Acetyl)-β-D-Glucopyranoside

📜4,6-Bis(Methoxymethyl)-2-(4-Acetoxy-3-Methoxybenzoyloxy)Acetophenone置于potassium Hydroxide,溶剂黄146,盐酸体系中,用 吡啶,水,甲醇 作为反应溶剂,化学反应 0.83H,以60%的收率获得产物金圣草(黄)素
参考文献:修饰的baker-Venkataraman转化法新合成乙酰乙酸甘油酯,油绿酚,薯in皂素,曲霉素和其他羟基化黄酮
标题:修饰的baker-Venkataraman转化法新合成乙酰乙酸甘油酯,油绿酚,薯in皂素,曲霉素和其他羟基化黄酮
摘要:Baker-Venkataraman(bv)重排是合成黄酮的选择方法.bv的主要局限性在于它需要对羟基进行广泛的保护和脱保护,这会使该过程冗长且麻烦.在本研究中,使用简单的保护基团和容易获得的原料开发了一种三步有效的方法.描述了新的合成醋氨蝶呤,瓜油酚,薯met皂素,甘油三酸酯和其他羟基黄酮.
DOI:10.2174/1570178611999140206115633

专利信息

专利号:WO-2025081225-A1
优先权日:2023-10-17
标 题 :Synthesis of polyphenols
发明人：TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
权利人:Delica Therapeutics Pty Ltd
摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-2024026314-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
发明人：ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.

专利号:US-9775856-B2
优先权日:2012-03-09
标题 :C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. therapeutic applications of the synthesized agent(s) and of Genista tenera ethyl acetate extracts containing some of those agents
发明人：GRASES SANTOS SILVA RAUTER AMÉLIA PILAR; XAVIER DE JESUS ANA RITA; MENDES MARTINS ALICE ISABEL; DOS SANTOS DIAS CATARINA ALEXANDRA; TAVARES RIBEIRO ROGÉRIO JOSÉ; BORGES DE LEMOS MACEDO MARIA PAULA; GUERRA JUSTINO JORGE ALBERTO; DIAS MOTA FILIPE HELDER; AMARO PINTO RUI MANUEL; NOGUEIRA SEPODES BRUNO MIGUEL; PATRÃ?CIO GOULART DE MEDEIROS MARGARIDA ALEXANDRA; JIMENÉZ BARBERO JESUS; AIROLDI CRISTINA; NICOTRA FRANCESCO
权利人:FACULDADE DE CIENCIAS DA UNIV DE LISBOA
摘要:The present invention concerns the antidiabetic-activity of compounds type A, namely of 8-β-D-glucosylgenistein, which is not toxic to eukaryotic cells and has demonstrated to produce complete normalization of fasting hyperglycaemia, to reduce excessive postprandial glucose excursion, to increase glucose-induced insulin secretion and insulin sensitivity. An alternative synthesis for this molecular entity and its binding ability to β-amyloid oligomers is also included in the present invention, which also comprises Genista tenera ethyl acetate extract for use as antihyperglycaemic, agent i.e. for lowering blood glucose levels in mammals that are pre-diabetic or have type 2 or type 1 diabetes. n The inhibitory activity of α-glucosidase by Genista tenera ethyl acetate and butanol extracts and that of glucose-6-phosphatase by these two extracts and the diethyl ether plant extract is also part of the present invention.