CAS: 38695-60-2; 2-(Methylsulfonyl)Thiophene

上下游产品

2-(methylsulfanyl)thiophene methyl iodide 2-Iodothiophene sodium methansulfinate 2-thiophensulfonamide 3-(5-methanesulfonylthiophene-2-yl)benzonitrile 2-(5-methanesulfonylthiophene-2-yl)benzonitrile 1-[4-(5-methanesulfonylthiophene-2-yl)-phenyl]ethanone

📜2-(甲硫基)噻吩置于二乙二醇二丁醚,氧气体系中,化学反应 20.0H,以73%的收率获得2-甲基磺酰噻吩
参考文献:在清洁条件下用分子氧选择性氧化(杂)硫化物
标题:在清洁条件下用分子氧选择性氧化(杂)硫化物
摘要:为将单一原材料转化为独特的高价值产品而开发的生态友好型和可转换催化系统的开发是一个特别吸引人的概念,也是一项艰巨的合成挑战.在本工作中,建立了在清洁条件下使用分子氧将硫化物有效选择性氧化为砜和亚砜的第一个实例.
Doi:10.1039/c9Gc03713F

专利信息

专利号:US-6995289-B2
优先权日:2000-08-02
标题 :Process for synthesis of alpha, beta-unsaturated ketones
发明人：PATEL IAN; HOPES PHILIP
权利人:ASTRAZENECA AB
摘要:A method for the synthesis of an α,β-unsaturated ketone useful for making substituted 1,4-dihydropyridines is described by reacting an aldehyde with pyrrolidine and then adding a ketone followed by trifluoroacetic acid at low temperature. The synthesis is used in a process for making substituted 1,4-dihydropyridines wherein a vinylogous amide is prepared by reacting a 1,3-cyclohexanedione with a phenylethylamine. The α,β-unsaturated ketone can be reacted with a vinylogous amide to form a 1,5-diketone which can be converted to a substituted 1,4-dihydropyridine.

专利号:US-7074931-B2
优先权日:2000-08-02
标 题:Process for asymmetric synthesis of substituted 1,4 -dihydropyridines
发明人：PATEL IAN; ASHWORTH IAN; LEVIN DANIEL
权利人:ASTRAZENECA AB
摘要:A process is described for reacting a vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound to form an 1,5-diketone which is converted to a 1,4-dihydropyridine. Asymmetric substituted 1,4-dihydropyridines are synthesized by the process by preparing an asymmetric vinylogous amide by reacting a 1,3-cyclohexanedione with a substantially homo-chiral phenylethylamine. Reaction of the asymmetric vinylogous amide with an α,β-unsaturated ketone in the presence of a silicon compound forms an asymmetric 1,5-diketone. The 1,5-diketone is converted to an asymmetric substituted 1,4-dihydropyridine.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2004039207-A1
优先权日:2000-08-02
标 题:Process for asymmetric synthesis of substituted 1,4 -dihydropyridines

专利号:WO-0210103-A1
优先权日:2000-08-02
标 题:PROCESS FOR SYNTHESIS OF α,β-UNSATURATED KETONES