专利号:US-2009137828-A1 优先权日:2005-08-18 标 题 :Synthesis of 1A-Fluoro-25-Hydroxy-16-23E-Diene-26,27-Bishomo-20-Epi-Cholecalciferol 发明人:USKOKOVIC MILAN R; MARCZAK STANISLAW; LOO RALF; VAN DER SLUIS MARCEL; JANKOWSKI PAWEL; MAEHR HUBERT 权利人:BIOXELL SPA 摘要:The invention provides a method of producing 20-methyl vitamin D3 compounds of formula (I). The method includes allylic and olefin oxidation, de-carbonylation, carbonyl reduction, fluoride substitution, epoxide deoxygenation, and Wittig-type couplings.
专利号:US-12071422-B2 优先权日:2022-02-07 标 题 :Process for synthesis of quinazoline compounds 发明人:LEBL RENE; LIM NGIAP KIE; MEIER ROLAND CHRISTOPH; ORCEL UGO JONATHAN; SEDELMEIER JOERG; SHEN JEFF; SIROIS LAUREN ELIZABETH; TIMMERMAN JACOB C; TRACHSEL ETIENNE; WHITE NICHOLAS ANDREW; XU JIE; ZHANG HAIMING; BACHMANN STEPHAN; BASS THOMAS MICHAEL; BIGLER RAPHAEL; BURKHARD JOHANNES ADRIAN; CLAGG KYLE BRADLEY PASCUAL; GOSSELIN FRANCIS; HAN CHONG; KALDRE DAINIS; KELLY SEAN M; HEROLD SEBASTIAN; LEITNER CHRISTIAN 权利人:GENENTECH INC; HOFFMANN LA ROCHE 摘要:Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.
专利号:AU-2006279331-A1 优先权日:2005-08-18 标 题 :Synthesis of 1alpha-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol
专利号:US-7678462-B2 优先权日:1999-06-10 标 题:Spin-on-glass anti-reflective coatings for photolithography 发明人:KENNEDY JOSEPH; BALDWIN TERESA; HACKER NIGEL P; SPEAR RICHARD 权利人:HONEYWELL INT INC 摘要:Anti-reflective coating materials for deep ultraviolet photolithography include one or more organic light-absorbing compounds incorporated into spin-on-glass materials. Suitable absorbing compounds are strongly absorbing over wavelength ranges around wavelengths such as 365 nm, 248 nm, and 193 nm that may be used in photolithography. A method of making absorbing spin-on-glass materials includes combining one or more organic absorbing compounds with alkoxysilane or halosilane reactants during synthesis of the spin-on-glass materials.
专利号:US-9839642-B2 优先权日:2014-05-09 标 题:Beta-tetrazolyl-propionic acids as metallo-beta-lactamase inhibitors 发明人:TANG HAIFENG; YANG SHU-WEI; MANDAL MIHIR; SU JING; LI GUOQING; PAN WEIDONG; TANG HAIQUN; DEJESUS REYNALDA; PAN JIANPING; HAGMANN WILLIAM; DING FA-XIANG; XIAO LI; PASTERNAK ALEXANDER; HUANG YUHUA; DONG SHUZHI; YANG DEXI 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to compounds of formula I that are metallo-β-lactamase inhibitors, the synthesis of such compounds, and the use of such compounds for use with β-lactam antibiotics for overcoming resistance.
专利号:US-12187755-B2 优先权日:2014-05-30 标题 :Minimal saponin analogues, synthesis and use thereof 发明人:GIN DAVID Y; CHEA ERIC K; FERNANDEZ-TEJADA ALBERTO; TAN DEREK S; LEWIS JASON S; GARDNER JEFFREY R; PILLARSETTY NAGAVARAKISHORE 权利人:MEMORIAL SLOAN KETTERING CANCER CENTER 摘要:Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.