CAS: 25631-05-4; 2-Amino-3-(4-Fluoro-1H-Indol-3-yl)Propanoic Acid

该化合物是氨酸锥虫的类似物,在蛋白环的4个位置上替换了氟质原子,该化合物被归类为非蛋白原氨基酸,这意味着在翻译过程中没有将其纳入蛋白质中.其分子结构包括一种无味,这是Treptophan的特征,还有氟化原子,能够影响其生化特性和相互作用.dl-4-氟化物在生物化学研究中很感兴趣,特别是与蛋白折叠,酶活性以及...

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    📜2-Acetamido-3-(4-Fluoro-1H-Indol-3-yl)Propanoic Acid置于盐酸,水体系中,用54 %的收率获得4-氟-Dl-色氨酸
    参考文献: Small Molecule Inhibitors Of The Crl4 Ubiquitin Ligase[fr] Inhibiteurs à Petites Molécules De L'Ubiquitine Ligase Crl4
    标题: Small Molecule Inhibitors Of The Crl4 Ubiquitin Ligase[fr] Inhibiteurs à Petites Molécules De L'Ubiquitine Ligase Crl4
    摘要:Compounds Of Formula (I),Compounds Of Formula (II),And Compounds Of Formula (III) Are Disclosed. Also Disclosed Are Compounds,Compositions,And Methods To Inhibit Cul4A Expression Or Activity,Cul4B Expression Or Activity,And/or Ddb1 Expression Or Activity For The Treatment Or Prevention Of Cancer,Dna Damage,Or Related Conditions. In Some Aspects,The Interaction Between Cul4A And/or Cul4B And The Beta-Propeller B Of Ddb1 Is Disrupted With The Compounds,Compositions,Or Methods.

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    专利信息


    专利号:US-11759496-B2
    优先权日:2016-05-10
    标题:Compounds and pharmaceutical use thereof in the treatment of cancer
    发明人：SUSIN SANTOS A; KAROYAN PHILIPPE; MERLE-BERAL HÉLÈNE
    权利人:KAROYAN PHILIPPE
    摘要:The present invention relates to a compound or a pharmaceutical salt thereof comprising a hexapeptide sequence of formula (I), its method of synthesis and its use in anticancer therapy. The invention also relates to a pharmaceutical composition for use in the treatment of cancer comprising at least one soluble peptide according to the invention or at least one acid nucleic according to the invention or at least one expression vector according to the invention, or at least one host cell according to the invention and a pharmaceutically acceptable carrier.

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    主要参考文献

    [参考文献]: A Ozarowski, Et Al. Phosphorescence And Optically Detected Magnetic Resonance Characterization Of The Environments Of Tryptophan Analogues In Staphylococcal Nuclease, Its V66W Mutant, And Delta 137-149 Fragment. Biochemistry. 1998 Jun 23;37(25):8954-64.
    [参考文献]: B Delagoutte, Et Al. Trna Aminoacylation By Arginyl-Trna Synthetase: Induced Conformations During Substrates Binding. Embo J. 2000 Nov 1;19(21):5599-610.
    [参考文献]: C Lian, Et Al. Fluorine-19 Nuclear Magnetic Resonance Spectroscopic Study Of Fluorophenylalanine- And Fluorotryptophan-Labeled Avian Egg White Lysozymes. Biochemistry. 1994 May 3;33(17):5238-45.
    [参考文献]: C Minks, Et Al. Atomic Mutations At The Single Tryptophan Residue Of Human Recombinant Annexin V: Effects On Structure, Stability, And Activity. Biochemistry. 1999 Aug 17;38(33):10649-59.
    [参考文献]: C Y Wong, Et Al. Incorporation Of Tryptophan Analogues Into Staphylococcal Nuclease, Its V66W Mutant, And Delta 137-149 Fragment: Spectroscopic Studies. Biochemistry. 1998 Jun 23;37(25):8938-46.

    合成参考文献


    参考文献:10.1128/jb.183.18.5414-5425.2001
    摘要:Bacher JM, Ellington AD. Selection and Characterization of Escherichia coli Variants Capable of Growth on an Otherwise Toxic Tryptophan Analogue. J Bacteriol. 2001 Sep 15;183(18):5414–25. doi: 10.1128/jb.183.18.5414-5425.2001.
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