专利号:US-5463131-A 优先权日:1994-06-30 标题 :Synthesis of organohaloboranes and alkoxyorganoboranes 发明人:BURKHARDT ELIZABETH R 权利人:MINE SAFETY APPLIANCES CO 摘要:A one-step process is provided for the synthesis of organohaloboranes, including diisopinocampheylchloroborane, and alkoxyorganoboranes. The present process does not utilize a thermally unstable ether adduct or a malodorous dimethyl sulfide adduct as required in prior processes. In general, the organohaloboranes are synthesized in a single reactor by reacting olefin(s) and/or alkyne(s) with boron trihalide and diborane. Alkoxyorganoboranes are synthesized in a single reactor by reacting olefin(s) and/or alkyne(s) with alkylborate and diborane.
专利号:EP-2647639-A1 优先权日:2012-04-06 标题:ß-boration of alkene and alkyne intermediates 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-borated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.
专利号:US-2016168138-A1 优先权日:2013-07-15 标题:Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant 发明人:IQBAL JAVED; DAHANUKAR VILAS HARESHWAR; ORUGANTI SRINIVAS; KANDAGATLA BHASKAR 权利人:REDDY S LAB LIMTED DR 摘要:A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)
专利号:US-4556712-A 优先权日:1981-05-20 标 题:Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines 发明人:RICE KENNER C 权利人:US HEALTH 摘要:In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids.
专利号:US-12054512-B2 优先权日:2017-11-10 标 题 :Sting modulator compounds, and methods of making and using 发明人:VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI 权利人:TAKEDA PHARMACEUTICALS CO 摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.
专利号:US-2009256111-A1 优先权日:2006-11-09 标题:Dialkylborane amine complexes 发明人:BURKHARDT ELIZABETH 权利人:BASF SE PATENTS TRADEMARKS AND 摘要:The present invention relates to new dialkylborane amine complexes, a process for the synthesis of new dialkylborane amine complexes, solutions comprising new dialkylborane amine complexes and a method of using new dialkylborane amine complexes for organic reactions.