CAS: 21932-54-7; Bis[(1R,3R,4S,5R)-4,6,6-Trimethyl-3-Bicyclo[3.1.1]Heptanyl]Boron

该化合物是一种源自(+)-α-pinne的手性巴内试剂,在非对称合成中广泛使用,特别是用于对准选择性地减少丙基酮,以产生具有高立体选择性的光学活性二次酒精,其主要优点包括:在减少量方面优异对应性过剩(ee),与一系列功能组相容,以及由于其定义明确的风力环境而可预见的立体化学结果.该试剂在合成药物和精密化学品方面特别有用,因为精确的风力控制至关重要.其空气和湿度的特性需要在惰性条件下进行处理.

结构式图片

MSDS等安全信息

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    CAS号7785-70-8 蒎烯 | CAS号14044-65-6 四氢呋喃硼烷络合物 | CAS号7785-70-8 蒎烯 | CAS号85134-98-1 (+)-B-甲氧基二异松莰基硼烷 | CAS号85116-37-6 (-)-二异松蒎基氯硼烷 | CAS号104114-70-7 (1R)-(-)-B-二异松蒎基溴硼烷 | CAS号1196-00-5 (-)-异松蒎醇

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      专利信息


      专利号:US-5463131-A
      优先权日:1994-06-30
      标题 :Synthesis of organohaloboranes and alkoxyorganoboranes
      发明人:BURKHARDT ELIZABETH R
      权利人:MINE SAFETY APPLIANCES CO
      摘要:A one-step process is provided for the synthesis of organohaloboranes, including diisopinocampheylchloroborane, and alkoxyorganoboranes. The present process does not utilize a thermally unstable ether adduct or a malodorous dimethyl sulfide adduct as required in prior processes. In general, the organohaloboranes are synthesized in a single reactor by reacting olefin(s) and/or alkyne(s) with boron trihalide and diborane. Alkoxyorganoboranes are synthesized in a single reactor by reacting olefin(s) and/or alkyne(s) with alkylborate and diborane.

      专利号:EP-2647639-A1
      优先权日:2012-04-06
      标题:ß-boration of alkene and alkyne intermediates
      权利人:LEK PHARMACEUTICALS
      摘要:The present invention relates to the field of organic chemistry, and in particular to the preparation of β-borated compounds. These β-borated compounds can be used as intermediates in the synthesis of pharmaceutically active agents such as Sitagliptin.

      专利号:US-2016168138-A1
      优先权日:2013-07-15
      标题:Process for the preparation of suvorexant and intermediates useful in the synthesis of suvorexant
      发明人:IQBAL JAVED; DAHANUKAR VILAS HARESHWAR; ORUGANTI SRINIVAS; KANDAGATLA BHASKAR
      权利人:REDDY S LAB LIMTED DR
      摘要:A novel processes for the preparation of suvorexant (formula I), its related compounds and its intermediates that are simple, economical and commercially viable. (I)

      专利号:US-4556712-A
      优先权日:1981-05-20
      标 题:Preparation and racemization of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines
      发明人:RICE KENNER C
      权利人:US HEALTH
      摘要:In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids.

      专利号:US-12054512-B2
      优先权日:2017-11-10
      标 题 :Sting modulator compounds, and methods of making and using
      发明人:VYSKOCIL STEPAN; CIAVARRI JEFFREY; CULLIS COURTNEY; ENGLAND DYLAN BRADLEY; GOULD ALEXANDRA E; GREENSPAN PAUL; HU YONGBO; LANGSTON STEVEN; LI GANG; MIZUTANI HIROTAKE; OKANIWA MASANORI
      权利人:TAKEDA PHARMACEUTICALS CO
      摘要:The present disclosure provides STING modulators/agonists, and methods of synthesis and methods for using for the prophylaxis or treatment of cancer and other STING-related diseases.The present disclosure relates to a compound represented by the Formula (I):wherein each symbol is as defined in the description, or a pharmaceutically acceptable salt thereof.

      专利号:US-2009256111-A1
      优先权日:2006-11-09
      标题:Dialkylborane amine complexes
      发明人:BURKHARDT ELIZABETH
      权利人:BASF SE PATENTS TRADEMARKS AND
      摘要:The present invention relates to new dialkylborane amine complexes, a process for the synthesis of new dialkylborane amine complexes, solutions comprising new dialkylborane amine complexes and a method of using new dialkylborane amine complexes for organic reactions.

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      品牌试剂参考报价(招募中)

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      ✅ COA系统入驻 | 共享模式

      合成参考文献


      摘要:Okamoto, K.; Ohe, K., Science of Synthesis Knowledge Updates, (2020) 1, 67.
      摘要:Molander, G. A.; Beaumard, F., Science of Synthesis Knowledge Updates, (2013) 3, 115.
      摘要:Fuchibe, K.; Ichikawa, J., Science of Synthesis Knowledge Updates, (2014) 2, 227.
      摘要:Tius, M. A., Science of Synthesis Knowledge Updates, (2022) 1, 464.
      摘要:Tius, M. A., Science of Synthesis Knowledge Updates, (2022) 1, 448.
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