4-Methoxy-Nicotinsaeureamid-1-Oxid置于五氯化磷,三氯氧磷体系中,化学反应生成2,4-二氯-3-氰基吡啶 参考文献:Pyridine-1-Oxides. Ii. A New Synthesis Of Ricinine1,2 标题:Pyridine-1-Oxides. Ii. A New Synthesis Of Ricinine1,2 摘要: Doi:10.1021/ja01582A059
专利号:US-2025163076-A1 优先权日:2022-02-18 标 题 :Synthesis of bruton's tyrosine kinase inhibitors 发明人:TRAN NGOC DUC; XIOURAS CHRISTOS; CLEATOR EDWARD; MATON WILLIAM MARC; RAMMELOO THOMAS JOACHIM LANDEWALD; FERNANDES PHILIPPE; BONGARTZ JEAN-PIERRE A; CAO DUY CHI TRUNG; HORWITZ MATTHEW ALLAN; JUSSEAU XAVIER JEAN-MARIE; LEMAIRE SÉBASTIEN FRANCOIS-EMMANUEL; SCHWEITZER-CHAPUT BERTRAND 权利人:JANSSEN PHARMACEUTICA NV 摘要:The present disclosure is directed to methods of synthesizing a compound of Formula (I), where the R groups are defined herein, and to methods of synthesizing a compound of Formula (II). Some aspects of the present disclosure is directed to converting the compound of Formula (II) into its P form.
专利号:WO-2023156599-A1 优先权日:2022-02-18 标 题 :Synthesis of bruton's tyrosine kinase inhibitors
专利号:EP-4479405-A1 优先权日:2022-02-18 标 题:Synthesis of bruton's tyrosine kinase inhibitors
专利号:CN-118715228-A 优先权日:2022-02-18 标题 :Synthesis of bruton's tyrosine kinase inhibitor
参考文献:10.1007/s12010-014-0764-y 摘要:He YC, Pan XH, Xu XF, Wang LQ. Biosynthesis of benzoylformic acid from benzoyl cyanide with a new bacterial isolate of Brevibacterium sp. CCZU12-1. Appl Biochem Biotechnol. 2014 Mar;172(6):3223–33. doi: 10.1007/s12010-014-0764-y.