CAS: 1649-18-9; 1-(4-Fluorophenyl)-4-(4-Pyridin-2-Ylpiperazin-1-yl)Butan-1-One

上下游产品

1-(2-pyridyl)piperazine 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 3-chloro-4'-fluoropropiophenoneazaperol

3'-氯-4-氟苯丙酮置于锰,二叔丁基过氧化物,三氟甲苯,碳酸氢钠,Potassium Iodide体系中,用 甲苯 用作溶剂,化学反应 84.0H,反应生成阿扎哌隆
参考文献:来自4-烷基-1,4-二氢吡啶的基于mn的自由基基烷基-烷基交叉偶联反应.
标题:来自4-烷基-1,4-二氢吡啶的基于mn的自由基基烷基-烷基交叉偶联反应.
摘要:β-氯酮及其衍生物的高效烷基化是通过多米诺脱氢/基于锰的自由基基烷基-烷基交叉偶联反应实现的.原位生成的α,β-不饱和酮及其类似物被确定为反应中间体.已知的生物活性化合物,例如美蓬酮和氮杂哌酮,可以很容易地由β-氯丙苯酮分两步制备.
Doi:10.1021/acs.Joc.9B02323

专利信息

专利号:US-12006301-B1
优先权日:2021-05-13
标题 :And synthesis of dual 5-HT1A and 5-HT7 receptor ligands
发明人：ABLORDEPPEY SETH Y
权利人:FLORIDA A&M UNIV
摘要:Novel dual 5-HT1A and 5-HT7 receptor ligands and methods of using the novel ligands to treat a neurological disorder are presented.

专利号:WO-2024110191-A1
优先权日:2022-11-22
标 题:Codon-optimized oligonucleotide for induction of elastin de-novo synthesis in mammals
发明人：AVCI-ADALI MELTEM; WENDEL HANS-PETER; GOLOMBEK SONIA
权利人:UNIV TUEBINGEN MEDIZINISCHE FAKULTAET
摘要:The present invention relates to oligonucleotides for induction of elastin de-novo synthesis in mammals, a method of treatment of diseases and medical conditions associated with insufficient tissue elasticity, use of the oligonucleotide in such treatment, as well as pharmaceutical and cosmetical compositions comprising such oligonucleotide.

专利号:US-9670217-B2
优先权日:2008-10-24
标题 :Process for preparing chlorins and their pharmaceutical uses
发明人：DA SILVA ARNAUT MOREIRA LUIS GUILHERME; PEREIRA MARIA MIGUÉNS; Formosinho SanchesSimõs Sebastião José; MAGALHÃES SIMÕES Sérgio Paulo; STOCHEL GRAZYNA; URBANSKA KRYSTYNA
权利人:DA SILVA ARNAUT MOREIRA LUIS GUILHERME; PEREIRA MARIA MIGUÉNS; Formosinho SanchesSimõs Sebastião José; MAGALHÃES SIMÕES Sérgio Paulo; STOCHEL GRAZYNA; URBANSKA KRYSTYNA; UNIV DE COIMBRA
摘要:The disclosed subject matter includes methods of preparation, properties, pharmaceutical compositions and methods of therapy of sulfonated chlorins and bacteriochlorins designed for the photodynamic therapy (PDT) of hyperproliferative tissues such as tumors, hyperproliferative blood vessels and other disorders or abnormalies that are responsive to PDT. In particular, the economical large-scale synthesis of stable chlorins and bacteriochlorins is described. Their properties were tailored to meet those of ideal photosensitizers for PDT. In another embodiment, pharmaceutical compositions and methods of therapy for systemic administration are provided. In a further embodiment, pharmaceutical compositions and methods of therapy for topical administration are also provided. Further provided is a method of labeling a target tissue and providing an image of that tissue by fluorescence of magnetic resonance imaging.

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÉREZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

专利号:CN-104477972-A
优先权日:2014-11-28
标题 :ZnIn2S4 photocatalyst obtained by hydrothermal synthesis of ionic liquid microemulsion and preparation method of ZnIn2S4 photocatalyst

专利号:CN-106188169-A
优先权日:2016-07-07
标题 :Synthesis of a Lipid Derivative Containing Sialic Acid Group and Its Application in Pharmaceutical Preparations