CAS: 1611-35-4; Xylenol Orange, Indicator

相似化合物

3618-43-7 1945-77-3 1733-12-6

专利信息

专利号:US-2017151351-A1
优先权日:2015-11-28
标 题:Gd-ENCAPSULATED CARBON DOTS AND METHODS OF MAKING AND USING THEREOF
发明人：XIE JIN; CHEN HONGMIN; LI ZIBO
权利人:UNIV GEORGIA
摘要:Gd-encapsulated carbonaceous dots (Gd@C-dots) hold great potential in clinical translation as Ti contrast agent for magnetic resonance imaging. However, current synthetic techniques yield particles with poor size control; hence, time-consuming size selection is often needed to obtain particles of desired sizes. Disclosed is a process whereby mesoporous silica nanoparticles are used as templates for size-controlled synthesis of Gd@C-dots. The disclosed methods involve calcining a mixture comprising a mesoporous silica nanoparticle, a gadolinium-containing compound, and a chelator, thereby forming the nanoparticles of gadolinium within the mesoporous silica nanoparticle; and removing the mesoporous silica nanoparticle from the nanoparticles of gadolinium.

专利号:US-12007376-B2
优先权日:2014-02-26
标题 :Method for determining a concentration of a synthesis component in a radiopharmaceutical sample
发明人：LEBEDEV ARTEM Y; ELIZAROV ARKADIJ M
权利人:TRACE ABILITY INC
摘要:A method for determining a concentration of a synthesis component in a radiopharmaceutical sample comprises providing an indicator, a metal or a metal complex, contacting the radiopharmaceutical sample with the indicator, metal or metal complex for a period of time sufficient to obtain an interaction, measuring an optical characteristic of the interacted components, and determining a concentration of the synthesis component in the radiopharmaceutical sample based on the measured optical characteristic.

专利号:US-11419953-B2
优先权日:2020-08-11
标 题:Reduced metastable complex macrocyclic contrast agents
发明人：DESLAURIERS RICHARD; MILBOCKER MICHAEL
权利人:INVENTURE LLC
摘要:Gadolinium based contrast agents (GCA) incorporating linear ligand chelation are fundamentally different from GCAs incorporating macrocyclic ligands. The macrocyclic\\GCAs are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. The synthesis of linear GCAs do not form metastable complexes. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species are not regulated and quickly release free Gd3+ ions upon administration into the body. Gadolinium based contrast agents with near zero metastable species content and methods of synthesizing the same are disclosed. Gadolinium based contrast agents with long dissociation time in the body, and low free Gd3+ ion formation are obtained using a synthesis method which departs in novel ways from the traditional free Gd3+-based synthesis methods.

专利号:US-2022242885-A1
优先权日:2021-02-01
标 题 :Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents
发明人：DESLAURIERS RICHARD J; MILBOCKER MICHAEL; LOMBARDO PAUL
权利人:INVENTURE LLC
摘要:Macrocyclic gadolinium-based contrast agents (GCA) are synthesized by pathways characterized by the formation of a sequence of metastable complexes before obtaining the final stable complex. Commercial macrocyclic GCAs contain unstable metastable complexes. These metastable species quickly release free Gd3+ ions upon delivery into the body. Aqueous or dry/solid GCA with near zero metastable species content and methods of synthesizing the same are disclosed.

专利号:US-2024208898-A1
优先权日:2021-03-25
标 题 :Enamine n-oxides: synthesis and application to hypoxia-responsive prodrugs and imaging agents
发明人：KIM JUSTIN; KANG DAHYE; CHEUNG SHELDON T
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are compounds and pharmaceutically acceptable salts and stereoisomers thereof that are suitable for diagnosis and the treatment of diseases and disorders characterized by, associate with or which exhibit tissue hypoxia, such as, for example, solid tumors. Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds.

专利号:WO-2024263911-A9
优先权日:2023-06-22
标题 :Methods for the synthesis and linearization of peptidomimetic macrocycles
发明人：KIM JUSTIN; FOWLER ELAINE
权利人:DANA FARBER CANCER INST INC
摘要:Disclosed are methodologies for the macrocyclization and linearization of peptides.