CAS: 1300031-52-0; 4-((2S,4R)-1-Acetyl-4-((4-Chlorophenyl)Amino)-2-Methyl-1,2,3,4-Tetrahydroquinolin-6-yl)Benzoic Acid

上下游产品

4-bromo-aniline bromobenzene brom°Chlorobenzene (S)-3-(N-phenylamino)-butyronitrile4-{(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-2-methyl-1,2,3,4-tetrahydro-6-quinolinyl}benzamide 2-((4-((2S,4R)-1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoyl)oxy)-N,N,N-trimethylethanaminium, formate 3-((4-((2S,4R)-1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoyl)oxy)-N,N,N-trimethylpropan-1-aminium, formate 3-(dimethylamino)propyl 4-((2S,4R)-1-acetyl-4-((4-chlorophenyl)amino)-2-methyl-1,2,3,4-tetrahydroquinolin-6-yl)benzoate

📜Isopropyl ((2S,4R)-1-Acetyl-6-Bromo-2-Methyl-1,2,3,4-Tetrahydroquinolin-4-yl)Carbamate置于四(三苯基膦)钯,Bis(Dibenzylideneacetone)-Palladium(0),2-二环己膦基-2'-(N,N-二甲胺)-联苯 Aluminum (III) Chloride,水,Sodium Hydroxide,Sodium T-Butanolate体系中,用 乙二醇二甲醚,乙醇,二氯甲烷,甲苯 用作溶剂,化学反应 25.01H,反应生成4-[(2S,4R)-1-乙酰基-4-[(4-氯苯基)氨基]-2-甲基-1,2,3,4-四氢-6-喹啉基]苯甲酸
参考文献: Thetrahydroquinolines Derivatives As Bromodomain Inhibitors[fr] Dérivés De Tétrahydroquinolines Convenant Comme Inhibiteurs Du Bromodomaine
标题: Thetrahydroquinolines Derivatives As Bromodomain Inhibitors[fr] Dérivés De Tétrahydroquinolines Convenant Comme Inhibiteurs Du Bromodomaine
摘要:公式(i)的四氢喹啉化合物或其盐,含有这种化合物的药物组合物及其在治疗中的应用,特别是在溴结构域抑制剂适用于治疗的疾病或症状.

专利信息

专利号:CN-118754894-A
优先权日:2024-07-26
标题 :JQ1 derivative containing o-naphthoquinone structure, synthesis method thereof and application of JQ1 derivative in preparation of anti-triple-negative breast cancer drugs

专利号:CN-118812557-A
优先权日:2024-07-26
标 题:BRD4/GPX4 double-target inhibitor, synthesis method thereof and application of inhibitor in preparation of triple-negative breast cancer therapeutic drug