CAS: 1184-78-7; Trimethylamine Oxide

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CAS号75-50-3 三甲胺 | CAS号62637-93-8 二水氧化三甲胺 | CAS号81752-56-9 trimethyl-amine... | CAS号77-78-1 硫酸二甲酯 | CAS号7722-84-1 过氧化氢 | CAS号7732-18-5 水 | CAS号67-66-3 氯仿 | CAS号10028-15-6 臭氧 | CAS号110-54-3 正己烷 | CAS号7239-24-9 N,N-二甲基异丁胺 | CAS号400-38-4 三氟乙酸异丙酯 | CAS号14917-12-5 Chromium,pentac... | CAS号5021-33-0 (1-甲基吡咯烷-3-基)甲醇 | CAS号51-28-5 2,4-二硝基酚 | CAS号593-81-7 三甲胺盐酸盐 | CAS号1670-17-3 Benzenamine,N,N... | CAS号837-64-9 2,4-二硝基-N,N-二乙基苯胺 | CAS号554-68-7 三乙胺盐酸盐 | CAS号24963-10-8 1-methyl-3,4-di...

📜三甲胺置于还原型辅酶ii(Nadph)四钠盐体系中,化学反应生成十二/十四烷基二甲基氧化胺
参考文献:膳食酚类及其微生物代谢物是肝黄素单加氧酶 3 将三甲胺氧化为三甲胺 N-氧化物的不良抑制剂
标题:膳食酚类及其微生物代谢物是肝黄素单加氧酶 3 将三甲胺氧化为三甲胺 N-氧化物的不良抑制剂
摘要:高循环水平的三甲胺n-氧化物 (Tmao) 与心血管疾病风险相关.Tmao 是通过主要利用膳食胆碱作为底物的微生物组-宿主途径形成的.特定的肠道微生物群将胆碱转化为三甲胺 (Tma),吸收后,宿主肝脏含黄素单加氧酶 3 (Fmo3) 将 Tma 氧化为 Tmao.绿原酸及其代谢物可减少体外微生物 Tma 的产生.然而,人们对绿原酸及其生物利用代谢物抑制最后一步(tma 肝脏转化为 Tmao)的潜力知之甚少.我们开发了一种筛选方法来研究 Fmo3 催化从 Tma 生产 Tmao.Hepg2 细胞由于缺乏 Fmo3 表达而无法将 Tma 氧化为 Tmao.虽然 Hepa-1 细胞在用 Tma 和 Nadph 预处理时确实表达 Fmo3,但它们缺乏产生 Tmao 的酶活性.大鼠肝微粒体含有活性 Fmo3.最佳反应条件为:50 µm Tma,0.2 Mm Nadph 和 33 µl 微粒体/ml 反应.200
Doi:10.1016/j.Jnutbio.2023.109428

专利信息

专利号:US-7344863-B2
优先权日:1998-03-13
标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
发明人：LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
权利人:INVITROGEN CORP
摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

专利号:US-9266915-B2
优先权日:2012-09-24
标题 :Synthesis of open metal carbonyl clusters
发明人：KATZ ALEXANDER S; KUPERMAN ALEXANDER; OKRUT ALEXANDER; RUNNEBAUM RON C; OUYANG XIAOYING
权利人:CHEVRON USA INC; UNIV CALIFORNIA
摘要:The present invention is directed to the synthesis of novel stable open metal clusters by selective oxidation of bound ligands. The synthesis comprises, for example, using an amine based oxidant for decarbonylation of specific carbonyl ligands. The synthesis can also comprise further removal of a bound amine group by an acid. The resulting metal cluster contains a coordinatively unsaturated site comprising a carbonyl vacancy. The resulting metal cluster can be used as a catalyst in a variety of chemical transformations.

专利号:US-10253153-B2
优先权日:2015-04-24
标题 :Linker and support for solid phase synthesis of nucleic acid, and production method of nucleic acid using said support
发明人：MAETA ERI; MORI KENJIRO; HORIE SHOHEI; ITO TAKAHIKO; SAITO SHOICHIRO; NAGAO RYUHEI
权利人:NITTO DENKO CORP
摘要:The present invention provides a linker for solid phase synthesis of nucleic acid, which consists of a compound represented by the formula (I) or the formula (II), a support for solid phase synthesis of nucleic acid, which has a structure represented by the formula (III), and a production method of a nucleic acid, which uses the support: n nwherein each symbol is as defined in the SPECIFICATION.

专利号:WO-2012001578-A1
优先权日:2010-06-29
标 题 :Single-step synthesis of iron oxide nanoparticles
发明人：BURDINSKI DIRK; HAEX NICOLE PETRONELLA MARTIEN
权利人:KONINKL PHILIPS ELECTRONICS NV; BURDINSKI DIRK; HAEX NICOLE PETRONELLA MARTIEN
摘要:The invention provides methods for the synthesis of iron oxide nanoparticles and the particles obtainable by these methods. The particles can be used as tracer materials for magnetic particle imaging and for Magnetic Particle Spectroscopy (MPS). The method for the synthesis of these particles comprises the steps: (i) dissolving at least one water-soluble iron salt and at least one water-soluble stabilizer in water to form a reaction batch, (ii) adding at least one base to the reaction batch to yield a pH of 10 to 13, and (iii) exposing the reaction batch to a reaction temperature T R for a defined period of time DT, wherein T R ≥ 110°C, to obtain the iron oxide nanoparticles.

专利号:US-12139504-B2
优先权日:2022-08-09
标 题:Vanadium alkylidene complex, synthesis and use thereof
发明人：BUKHRYAKOV KONSTANTIN; BELOV DMITRY
权利人:BUKHRYAKOV KONSTANTIN; BELOV DMITRY; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides catalytical compounds/complexes, compositions comprising such compound/complex, synthesis of the compounds/complexes, and methods of using such compounds/complexes as catalysts in, for example, RCM reactions. Specifically, the subject invention provides the synthesis of the first catalytically active V oxo alkylidene, VO(CHSiMe 3 )(PEt 3 ) 2 Cl, which exhibits superior performance compared to other analogs.

专利号:US-9994508-B2
优先权日:2012-12-11
标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives
发明人：LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO
权利人:ENDOTHERM GMBH
摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.