CAS: 1150310-15-8; (E)-3-(3,4-Dihydroxy-5-Nitrophenyl)-2-(Piperidine-1-Carbonyl)Acrylonitrile

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1-cyanoacetylpiperidine 3,4-dihydroxy-5-nitrobenzaldehyde piperidine (2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-2-propenoyl chloride

📜3,4-二羟基-5-硝基苯甲醛置于哌啶,氯化亚砜,溶剂黄146体系中,用 乙醇 用作溶剂,化学反应 4.0H,反应生成(Alphae)-Alpha-[(3,4-二羟基-5-硝基苯基)亚甲基]-Beta-氧代-1-哌啶丙腈
参考文献:Efficient Approach To Pure Entacapone And Related Compounds
标题:Efficient Approach To Pure Entacapone And Related Compounds
摘要:A New And Efficient Process Through A New Intermediate,(2E)-2-Cyano-3(3,4-Dihydroxy-5-Nirtrophenyl)Prop-2-Enoic Acid 15,Has Been Described For Preparing Substantially Pure Entacapone 1. This New Intermediate 15 Was Prepared By Knoevenagel Condensation Of 3,4-Dihydroxy-5-Nitrobenzaldehyde 2 With 2-Cyanoacetic Acid 14 And Was Further Condensed With Diethylamine To Get Pure Entacapone 1. Some Of The Important Process-Related Impurities Of Entacapone (17,18,19,And 20) Were Also Prepared Easily From This Intermediate 15.
Doi:10.1080/00397911.2010.539894