CAS: 1121-78-4; 5-Hydroxy-2-Methylpyridine

相似化合物

1121-25-1 1122-43-6 31191-08-9

上下游产品

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6-Methyl-1-Tosyl-1,6-Dihydropyridin-3-Yl Acetate置于potassium Hydroxide,氯化铵体系中,用 四氢呋喃,甲醇,水 用作溶剂,化学反应 0.5H,以84%的收率获得3-羟基-6-甲基吡啶
参考文献:铑催化4-(1-乙酰氧基烯丙基)-1-磺酰基-1,2,3-三唑的串联反应合成1,2-二氢吡啶
标题:铑催化4-(1-乙酰氧基烯丙基)-1-磺酰基-1,2,3-三唑的串联反应合成1,2-二氢吡啶
摘要:据报道,4-(1-乙酰氧基烯丙基)-1-磺酰基-1,2,3-三唑的串联反应包括形成α-亚氨基铑卡宾,乙酰氧基的1,2-迁移和六个电子环的闭合.具有出色的化学选择性的oac基团的迁移是关键过程,特别是导致1,2-二氢吡啶的形成,产率高达90%.还实现了二氢吡啶产物的几次转化,说明了该方案在有机合成中的潜力.基于对中间体的观察,提出了一个合理的机制.
Doi:10.1039/c7Cc02521A

专利信息

专利号:US-5760237-A
优先权日:1995-08-25
标 题 :Synthesis of l-azatyrosine using pseudoephedrine as a chiral auxiliary
发明人：MYERS ANDREW G
权利人:CALIFORNIA INST OF TECHN
摘要:A practical synthesis of the potential chemotherapeutic agent L-azatyrosine is described. The key step involved the alkylation of (R,R)-(-)-pseudoephedrine glycinamide with 5-benzenesulfonyloxy-2-iodomethylpyridine and proceeded in 70-95% yield and 89-95% de. Simultaneous hydrolysis of the auxiliary and the benzenesulfonate protecting group afforded L-azatyrosine of ≧99% ee in 73% yield on multigram scale (recovery yield of (R,R)-(-)-pseudoephedrine: 90%).

专利号:US-8664402-B2
优先权日:2011-03-09
标题:Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methylsulfonyl)phenyl]ethanone, an intermediate of etoricoxib
发明人：CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO
权利人:CASTELLIN ANDREA; STABILE PAOLO; FONTANA FRANCESCO; DE LUCCHI OTTORINO; CAPORALE ANDREA; TARTAGGIA STEFANO; ITALIANA SINT SPA
摘要:A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.

专利号:RU-2024511-C1
优先权日:1986-04-17
标 题 :Method of synthesis of e-isomers of acrylic acid derivatives

专利号:US-9670230-B2
优先权日:2012-11-29
标题 :Heteroaryl compounds and methods of use thereof
发明人：CAMPBELL JOHN EMMERSON; JONES PHILIP
权利人:SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

专利号:US-6936600-B2
优先权日:1999-04-01
标题:Sorbitol dehrydrogenase inhibitors
发明人：CHU-MOYER MARGARET Y; MYLARI BANAVARA L; ZEMBROWSKI WILLIAM J
权利人:PFIZER
摘要:This invention is directed to sorbitol dehydrogenase inhibitory compounds of the formula I, n n nwherein R 1 , R 2 and R 3 are as defined in the specification. This invention is also directed to pharmaceutical compositions containing those compounds and methods of treating or preventing diabetic complications, particularly diabetic neuropathy, diabetic nephropathy, diabetic microangiopathy, diabetic macroangiopathy and diabetic cardiomyopathy by administering such compounds to a mammal suffering from diabetes and therefore at risk for developing such complications. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an aldose reductase inhibitor and to methods of treating or preventing diabetic complications therewith. This invention is also directed to pharmaceutical compositions comprising a combination of a compound of formula I of this invention with an NHE-1 inhibitor and to methods of treating cardiomyopathy and other heart-related problems therewith. This invention is also directed to certain intermediates used in the synthesis of the compounds of formula I and to processes for preparing those intermediates.

专利号:US-5998451-A
优先权日:1987-10-19
标 题 :Substituted tetralins, chromans and related compounds in the treatment and related compounds in the treatment of asthma, arthritis and related diseases
发明人：EGGLER JAMES F; MARFAT ANTHONY; MELVIN JR LAWRENCE S
权利人:PFIZER
摘要:Substituted tetralins, chromans and related compounds which, by inhibiting 5-lipoxygenase enzyme and/or blocking leukotriene receptors, are useful in the prevention or treatment of asthma, arthritis, psoriasis, ulcers, myocardial infarction and related disease states in mammals, pharmaceutical compositions thereof, a method of treatment therewith, and to intermediates useful in the synthesis thereof.