CAS: 104-81-4; 1-(Bromomethyl)-4-Methylbenzene

相似化合物

623-24-5 57825-30-6 620-13-3

上下游产品

brom°Cyane 2-methylbenzyl 4-methylbenzyl sulfide ethyl-benzyl-(4-methyl-benzyl)-amine methyl-(3-methyl-benzyl)-(4-methyl-benzyl)-amine 2-benzoyl-1-(4-methyl-benzyl)-pyridinium; picrate ethyl-benzyl-(4-methyl-benzyl)-amine p-butyltoluene 4-methyl-benzaldehyde

对甲基苯甲酸甲酯置于lithium Aluminium Tetrahydride,三溴化磷体系中,用 四氢呋喃,二氯甲烷 用作溶剂,化学反应生成4-甲基苄溴
参考文献:作为潜在选择性抗癌剂的 (Z)-苯乙烯基苯衍生物的合成和表征.
标题:作为潜在选择性抗癌剂的 (Z)-苯乙烯基苯衍生物的合成和表征.
摘要:为了鉴定高效低毒的抗癌药物,合成了一系列 (Z)-苯乙烯基苯衍生物,并使用一组九种癌细胞系和两种非癌细胞系评估其抗癌活性.大多数衍生物对五种癌细胞系(包括 Mgc-803 和 Bel-7402)表现出显着的抗增殖活性. (Z)-3-(P-Tolyl)-2-(3,4,5-三甲氧基苯基)丙烯腈(6H)对mgc-803细胞表现出强烈的抑制作用(Ic50 < 0.01 µm),并表现出更强的抗增殖活性比紫杉醇 (Ic50 < 0.06 +/-0.01 µm). L-02细胞中6小时的ic50值比mgc-803细胞中高10,000倍.化合物6H通过上调细胞周期蛋白b1表达,下调细胞周期蛋白a和d1表达以及诱导细胞凋亡,将bel-7402细胞阻滞在g2/m期,从而抑制bel-7402细胞的增殖.此外,6H抑制bel-7402细胞的迁移和细胞集落的形成.
Doi:10.1080/14756366.2018.1513925

专利信息

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-9085550-B2
优先权日:2005-01-21
标题 :Ligands for estrogen related receptors and methods for synthesis of said ligands
发明人：FORMAN BARRY; YU DONNA
权利人:FORMAN BARRY; YU DONNA; HOPE CITY
摘要:Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.

专利号:US-9879043-B1
优先权日:2013-06-06
标 题:Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase
发明人：THORSON JON; HUBER TYLER; ZHANG JIANJUN; Singh Shanteri
权利人:UNIV KENTUCKY RES FOUND
摘要:The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: n nwhere X is S or Se, and R 1 is an alkyl group.

专利号:US-6710208-B2
优先权日:1996-12-19
标题 :Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARMA INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-2024209029-A1
优先权日:2021-04-21
标题:Adiponectin glycopeptides and compositions and methods of use thereof
发明人：WANG YU; LI XUECHEN; XU AIMIN; WU HONGXIANG; ZHANG YIWEI; LI YUANXIN
权利人:UNIV HONG KONG
摘要:An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.