CAS: 100-75-4; N-Nitrosopiperidine

该化合物是一种化学化合物,被归类为硝基胺,以其潜在的致癌特性而闻名,由含有硝酸的环状铁矿,环状铁矿的反应形成,该化合物一般为黄色至褐色的,有特质的气味的青黄液体.N-硝基乙基丙烯在有机溶剂中可溶解,但水溶性有限.其分子结构中含有一个带有硝基索组(-N=O)的管状环,有助于其反应和生物活动.该物质主要与毒理学和环境化学有关,因为它在各种化学过程中形成,并存在于某些食品和烟草中.接触N-硝基硫酸与实验室动物癌症风险增加有关,促使监管检查.适当的处理和处置对于减轻其潜在健康风险至关重要,在许多管辖区被归类为危险物质.

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CAS号626-67-5 1-甲基哌啶 | CAS号110-89-4 六氢吡啶 | CAS号766-09-6 1-乙基哌啶 | CAS号509-14-8 四硝基甲烷 | CAS号2213-43-6 1-氨基哌啶 | CAS号6091-45-8 nitric acid,pip... | CAS号70570-05-7 1,1-dinitro-N-(... | CAS号17206-00-7 1-甲基哌啶1-氧化物 | CAS号68712-54-9 1-methyl-3,4-di... | CAS号94-62-2 胡椒碱 | CAS号1055-23-8 9,9'-二蒽 | CAS号84914-82-9 10-ethoxy-9-ant... | CAS号110-89-4 六氢吡啶 | CAS号2213-43-6 1-氨基哌啶 | CAS号7664-41-7 氨 | CAS号138-89-6 N,N-二甲基-4-亚硝基苯胺 | CAS号6956-56-5 Ethanone,2,2-di... | CAS号4589-97-3 Benzeneacetalde...

合成工艺路线路线简述

    📜N-甲基哌啶置于硝酸,乙酸酐体系中,用32%的收率获得n-亚硝基哌啶
    参考文献:Boyer; Pillai; Ramakrishnan,Synthesis,1985,Vol. No. 6-7,# 6/7,P. 677-677
    标题:Boyer; Pillai; Ramakrishnan,Synthesis,1985,Vol. No. 6-7,# 6/7,P. 677-677

    专利信息


    专利号:US-7879999-B2
    优先权日:2003-12-17
    标 题:Method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines
    发明人：DELALU HENRI; COLAS-DURICHE CECILE; BERTHET JACQUES; LEURENT PHILIPPE
    权利人:ISOCHEM SA; CENTRE NAT RECH SCIENT; UNIV CLAUDE BERNARD LYON
    摘要:The invention relates to a method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines The invention is characterised in that the method comprises a step consisting in demixing a solution containing said synthesised derivative, by reacting a heterocyclic amine with monochloramine, in an organic phase and an aqueous phase with the addition of anhydrous sodium hydroxide. According to the invention, the starting amine which has not reacted is collected and reused directly without any additional treatment. The inventive method can also be used to obtain the corresponding exocyclic heterocycloalkyl-hydrazine or cycloalkyl-hydrazinederivative derivative at a low cost compared to that of other known methods.

    专利号:US-2007249829-A1
    优先权日:2003-12-17
    标题 :Method for the Synthesis of Exocyclic Derivatives of Cycloalkyl-Hydrazines and Exocyclic Derivatives of Heterocycloalkyl-Hydrazines

    专利号:EP-1699770-A1
    优先权日:2003-12-17
    标 题 :Method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines

    专利号:CN-107602415-A
    优先权日:2017-09-25
    标 题:A kind of Fe(â…¢) porphyrin-catalyzed method for the one-pot synthesis of aromatic nitriles by oxidizing aromatic olefins with nitrite

    专利号:WO-2005058852-A1
    优先权日:2003-12-17
    标题 :Method for the synthesis of exocyclic derivatives of cycloalkyl-hydrazines and exocyclic derivatives of heterocycloalkyl-hydrazines

    专利号:CN-107573259-A
    优先权日:2017-09-25
    标 题:A method for the synthesis of aromatic nitriles from aromatic olefins catalyzed by metalloporphyrins

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    合成参考文献


    摘要:Siatkin SP, Berezov TT. [Ornithine decarboxylase activity in malignant tumors]. Vopr Med Khim. 1980 Jan;26(1):121–4.
    摘要:Cancer Letters, 21(219), 1983 []
    摘要:Zeitschrift fuer Krebsforschung und Klinische Onkologie., 81(251), 1974 []
    摘要:Currance, P.L. Clements, B., Bronstein, A.C. (Eds).; Emergency Care For Hazardous Materials Exposure. 3Rd edition, Elsevier Mosby, St. Louis, MO 2005, p. 287
    摘要:Gloria MBA et al; J Agric Food Chem 45: 1816-8 (1997)
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