CAS: 99135-95-2; (3R,4R)-1-Benzyl-3,4-Bis(Diphenylphosphino)Pyrrolidine

上下游产品

CAS号90365-74-5 (3S,4S)-1-苄基吡咯烷... | CAS号100-46-9 苄胺 | CAS号75172-31-5 (3R,4R)-3,4-二羟基...

📜(3S,4S)-1-苄基吡咯烷-3,4-二醇置于三乙胺体系中,用 二氯甲烷,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 0.5H,反应生成 (+)-N-苄基-(3R,4R)-双(二苯基膦)吡咯烷
参考文献:Nagel,Ulrich; Kinzel,Elke; Andrade,Juan,Chemische Berichte,1986,Vol. 119,# 11,P. 3326-3343
标题:Nagel,Ulrich; Kinzel,Elke; Andrade,Juan,Chemische Berichte,1986,Vol. 119,# 11,P. 3326-3343

专利信息

专利号:US-10745354-B2
优先权日:2017-11-01
标题 :Methods for enantioselective allylic alkylation of esters, lactones, and lactams with unactivated allylic alcohols
发明人：STOLTZ BRIAN M; NGAMNITHIPORN AURAPAT; JETTE CARINA I; BACHMAN SHOSHANA; VIRGIL SCOTT C; LACKNER SEBASTIAN
权利人:CALIFORNIA INST OF TECHN
摘要:The present disclosure provides methods for enantioselective synthesis of cyclic and acyclic α-quaternary carboxylic acid derivatives via nickel-catalyzed allylic alkylation.

专利号:US-6380416-B2
优先权日:1997-06-13
标题:Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

专利号:EP-1030854-B1
优先权日:1997-11-12
标题 :Catalysts for asymmetric synthesis containing rigid chiral ligands
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:This invention is to develop novel transition metal catalysts for the pratical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity.

专利号:US-7495123-B2
优先权日:2004-04-05
标 题:Process for the preparation of enantiomerically enriched beta amino acid derivatives
发明人：XIAO YI; SUN YONGKUI; ROSNER THORSTEN; RIVERA NELO R; KRSKA SHANE W; CLAUSEN ANDREW M; ARMSTRONG III JOSEPH D; SPINDLER FELIX; MALAN CHRISTOPHE
权利人:SOLVIAS AG; MERCK & CO INC
摘要:The present invention relates to a process for the efficient preparation of enantiomerically enriched beta amino acid derivatives wherein the amino group is unprotected. The product chiral beta amino acid derivatives are useful in the asymmetric synthesis of biologically active molecules. The process comprises an enantioselective hydrogenation of an amine-unprotected prochiral beta-amino acrylic acid or derivative thereof in the presence of a rhodium metal precursor complexed with a chiral mono- or bisphosphine ligand.

专利号:US-6399787-B1
优先权日:1997-06-13
标 题:Catalytic asymmetric hydrogenation, hydroformylation, and hydrovinylation via transition metal catalysts with phosphines and phosphites
发明人：ZHANG XUMU
权利人:PENN STATE RES FOUND
摘要:Novel transition metal catalysts with conformationally rigid chiral phosphines and phosphites are developed for asymmetric carbon-hydrogen and carbon-carbon bond formation. The invention emphasizes synthesis of chiral amines, beta-amino acids and related compounds via catalytic asymmetric hydrogenation based on chiral monodentate and bidentate phosphines with cyclic ring structures. The ligands contain rigid ring structures.

专利号:US-9403766-B2
优先权日:2008-01-17
标 题:Intermediates for producing NEP inhibitors or prodrugs thereof
发明人：HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO
权利人:HOOK DAVID; RISS BERNARD; KAUFMANN DANIEL; NAPP MATTHIAS; BAPPERT ERHARD; POLLEUX PHILIPPE; MEDLOCK JONATHAN; ZANOTTI-GEROSA ANTONIO; NOVARTIS AG
摘要:The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, n nwherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.