CAS: 845959-50-4; (10-(4,5-Dimethoxy-2-Methyl-3,6-Dioxocyclohexa-1,4-Dien-1-yl)Decyl)Triphenylphosphonium Methanesulfonate

📜[10-(2,5-Dihydroxy-3,4-Dimethoxy-6-Methylphenyl)Decyl]Triphenylphosphonium,Monomethanesulfonate 以94的收率获得产物米托蒽醌甲磺酸盐
参考文献:Mitoquinone Derivatives Used As Mitochondrially Targeted Antioxidants
标题:Mitoquinone Derivatives Used As Mitochondrially Targeted Antioxidants
摘要:本发明涉及药学上可接受的两性亲水抗氧化剂化合物,包含该化合物的组合物和剂型,以及依赖于该化合物的方法和用途.所示的化合物都是丙酮酸脱氢酶抑制剂衍生物,是甲氧基苯基烷基三苯基膦或甲氧基二氧杂环己二烯烷基三苯基膦衍生物.该化合物,组合物,剂型,用途和方法在治疗与氧化应激有关的疾病或病况方面是有用的.

专利信息

专利号:US-2024336586-A1
优先权日:2021-07-29
标题:Methods for synthesis of racemic, scalemic, and chiral alpha-tocotrienol quinone
发明人：GIANNOUSIS PETER; MOLLARD PAUL; GOUDEDRANCHE SEBASTIEN; KARASAWA TOMOYA
权利人:PTC THERAPEUTICS INC
摘要:The application discloses methods useful for the synthesis of racemic, scalemic, and chiral alpha-tocotrienol quinone, including synthetic intermediates and methods for making said synthetic intermediates.

专利号:US-11897910-B2
优先权日:2015-06-11
标 题:Mito-honokiol compounds and methods of synthesis and use thereof
发明人：KALYANARAMAN BALARAMAN; ZIELONKA JACEK MICHAL; CHENG GANG; HARDY MICAEL J; OUARI OLIVIER; YOU MING
权利人:MEDICAL COLLEGE WISCONSIN INC; AIX MARSEILLE UNIV
摘要:The present invention provides mito-honokiol or mito-magnolol compounds, pharmaceutical compositions thereof, and methods of using the mito-honokiol or mito-magnolol compounds in the treatment of cancer.

专利号:US-11078222-B2
优先权日:2016-12-29
标题:Hydroxybenzoic acid derivatives, methods and uses thereof
发明人：MARTINS BORGES MARIA FERNANDA; GOUVEIA SIMÕËS DA SILVA OLIVEIRA PAULO JORGE; SANTOS TEIXEIRA JOSÉ CARLOS; CAGIDE FAGIN FERNANDO; GOMES OLIVEIRA ANA CATARINA
权利人:UNIV DO PORTO; CENTRO DE NEUROCIENCIAS E BIOLOGIA CELULAR
摘要:The present disclosure relates to the design and synthesis of new mitochondriotropic antioxidant compounds based on hydroxybenzoic acids and analogues. Furthermore, this disclosure is also related to the methods and uses of the hydroxybenzoic based derivatives and analogues, for example, in the field of human and animal diseases, for instance to treat mitochondrial dysfunction or mitochondrial deficiencies, and cosmetics, for instance to prevent or delay skin aging.

专利号:EP-4377302-A1
优先权日:2021-07-29
标题 :Methods for synthesis of racemic, scalemic, and chiral alpha-tocotrienol quinone

专利号:US-2010173939-A1
优先权日:2008-12-22
标题:Antiviral compounds
发明人：LINK JOHN O
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infection. n n n n n n n n n n n n R 1 is:

专利号:US-2010160403-A1
优先权日:2008-12-19
标题 :Hcv ns3 protease inhibitors
发明人：LINK JOHN O; VIVIAN RANDALL W
权利人:GILEAD SCIENCES INC
摘要:The present invention relates to macrocyclic compounds of formula (Ia) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.