CAS: 79781-21-8; 4-(2-Chlorophenyl)-3-Ethoxycarbonyl-2-Hydroxymethyl-6-Methyl-1,4-Dihydropyridine

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上下游产品

4-(2-Chloro-phenyl)-2-formyl-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester 2-carboxy-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 2-chloro-benzaldehyde methyl 3-amin°Crotonate 3-ethyl 5-methyl 2-(chloromethyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate 2-(2-aminoethylthiomethyl)-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine 3-ethyl 5-methyl 2-((amidinomethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methylpyridine-3,5-dicarboxylate

合成工艺路线路线简述

  • 合成目标产物 Amlodipine Impurity 28 主要起始原料 Ethyl 2-Acetoxymethyl-4-(2-Chlorophenyl)-1,4-Dihydro-5-Methoxycarbonyl-6-Methyl-3-Pyridinecarboxylate
  • 129207-93-8 = 79781-21-8
    反应条件:1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran1.2 Reagents: Lithium Aluminum Hydride
    标题:The Synthesis Of 2-Substituted-1,4-Dihydropyridines
    作者:Alker,D.; Et Al
    参考文献:Tetrahedron 日期:1990 卷标:46(10) 页码:3693-702]

    108-56-5 + 89-98-5 + 14205-39-1 = 79781-21-8
    反应条件:1.1 Solvents: Methanol1.2 Reagents: Sodium Hydroxide Solvents: 1,4-Dioxane2.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran2.2 Reagents: Lithium Aluminum Hydride
    标题:The Synthesis Of 2-Substituted-1,4-Dihydropyridines
    作者:Alker,D.; Et Al
    参考文献:Tetrahedron 日期:1990 卷标:46(10) 页码:3693-702
📜β-氨基巴豆酸甲酯置于sodium Hydroxide,Sodium Tetrahydroborate,Lithium Aluminium Tetrahydride,N,N'-羰基二咪唑体系中,用 1,4-二氧六环,甲醇 作为反应溶剂,化学反应 34.5H,反应生成 氨氯地平杂质28
参考文献:The Synthesis Of 2-Substituted-1,4-Dihydropyridines
标题:The Synthesis Of 2-Substituted-1,4-Dihydropyridines
摘要:
DOI:10.1016/s0040-4020(01)81539-8

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主要参考文献

参考标题:Asymmetric Synthesis Of (R)-Nilvadipine And (S)-Nb 818 Via Regioselective Bromination Of Chiral 1,4-Dihydropyridines As A Key Step And Enzymatic Resolution Of Racemic 2-Hydroxymethyl-1,4-Dihydropyridine Derivatives.
作者:Hirosato Ebiike,Kaori Maruyama,Yumi Ozawa,Yukiyoshi Yamazaki,Kazuo Achiwa
摘要:Optically Active 2-Hydroxymethyl-1, 4-Dihydropyridines Were Obtained By Lipase-Catalyzed Hydrolysis Or Transesterification Of Racemic Materials. Chiral Nb 818 And Nilvadipine Have Been Synthesized From Chiral 2-Hydroxymethyl-1, 4-Dihydropyridine. On The Other Hand, Chiral 1, 4-Dihydropyridines Obtained From Prochiral Substrates Have Been Converted Into (S)-Nb 818 And (R)-Nilvadipine Via Regioselective Bromination Of Methyl Groups Under Mild Conditions.

合成参考文献

参考DOI号:10.1371/journal.pone.0109206
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