CAS: 75345-27-6; Polyquaternium 1

该化合物是一种合成聚合物,属于四化合物类别,主要用于个人护理产品,特别是发型,香波和皮肤护理配方,因为其调制和造影性能较低,众所周知,这种聚合物能够改善头发的纹理和可管理性,提供光滑和柔软的感应;多-1是水溶的,与各种表面活性剂具有良好的兼容性,使其在配方中具有有效的成分;此外,它具有抗微生物特性,可以加强化妆品的保存;一般认为聚合物在化妆品和个人护理物品中使用是安全的,皮肤和眼睛的刺激潜力较低;其特性使其能够坚持负电表面,如毛发和皮肤,提供长期的调控效果;总的来说,多-1在加强化妆品的性能和感官特性方面,具有多功能效益,因此受到重视.

结构式图片

欧盟法规

C&L通报

合成工艺路线路线简述

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    专利信息


    专利号:US-2024400552-A1
    优先权日:2016-11-11
    标题 :Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS I; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by dysregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-11622968-B2
    优先权日:2011-03-08
    标 题:Heterocyclic modulators of lipid synthesis
    发明人:BUCKLEY DOUGLAS; DUKE GREGORY; WAGMAN ALLAN S; EVANCHIK MARC; MCDOWELL ROBERT S
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and/or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatitis C infection, cancer and metabolic disorders, such as non-alcoholic steatohepatitis (NASH).

    专利号:US-2025017938-A1
    优先权日:2023-06-20
    标 题:Combination therapies of fasn inhibitors with thyroid hormone receptor agonists
    发明人:O'FARRELL ANNE-MARIE; KEMBLE GEORGE; TSAI WEN-WEI
    权利人:SAGIMET BIOSCIENCES INC
    摘要:Therapeutic combinations of fatty acid synthesis modulators and thyroid hormone receptor agonists are provided. The combinations may be used to treat disorders including metabolic disorders and liver disorders, such as nonalcoholic steatohepatitis/metabolic dysfunction-associated steatohepatitis (NASH/MASH).

    专利号:EP-4206236-A1
    优先权日:2021-12-28
    标题 :Compounds, their synthesis and compositions comprising the compounds for enhanced deposition of polymers onto hair surfaces
    发明人:BREAKSPEAR STEVEN; NÖCKER BERND; WEITZEL JOHANNA; PAEZ JULIETA; PEARSON SAMUEL; BRÜCK STEFAN; CAMPO ARANZAZU DEL
    权利人:KAO CORP
    摘要:The present invention is on polymers derivatized with an organic deposition-enhancing group for their enhanced deposition onto keratin fibers, especially human hair. The deposition-enhancing group is a di-hydroxyl phenolic compound with a spacer alkyl group bound to a reactive amine or carboxyl group, which reacts with one of the hydroxyl, carboxyl, primary and secondary amine groups on the polymeric backbone. The invention is on the method of synthesizing such compounds and compositions comprising the compounds.

    专利号:US-2022296605-A1
    优先权日:2011-03-08
    标 题 :Heterocyclic modulators of lipid synthesis

    专利号:US-2022340556-A1
    优先权日:2016-11-11
    标 题 :Heterocyclic modulators of lipid synthesis

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    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Kinnunen K, Kauppinen A, Piippo N, Koistinen A, Toropainen E, Kaarniranta K. Cationorm shows good tolerability on human HCE-2 corneal epithelial cell cultures. Exp Eye Res. 2014 Mar;120:82-9. doi: 10.1016/j.exer.2014.01.006. Epub 2014 Jan 22. Japanese.

    合成参考文献


    摘要:S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118
    参考文献:10.1007/s12325-011-0029-x
    摘要:Ammar DA, Noecker RJ, Kahook MY. Effects of benzalkonium chloride- and polyquad-preserved combination glaucoma medications on cultured human ocular surface cells. Adv Ther. 2011 Jun;28(6):501–10. doi: 10.1007/s12325-011-0029-x.
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