CAS: 68322-84-9; 2-Bromo-1-Fluoro-4-(Trifluoromethyl)Benzene

上下游产品

4-Fluorobenzotrifluoride

4-氟三氟甲苯置于ferric(Iii) Bromide,硫酸,四丁基溴化铵,溴,Lithium Bromide体系中,化学反应 6.0H,以95.94%的收率获得产物3-溴-4-氟三氟甲苯
参考文献:一种制备2-溴-5-氟三氟甲苯的方法
标题:一种制备2-溴-5-氟三氟甲苯的方法
摘要:本发明公开了一种制备2‑溴‑5‑氟三氟甲苯的方法,所述的制备方法以间氟三氟甲苯为原料,在浓硫酸,复合催化剂的条件下,搅拌滴加溴素,经过分离和提纯后得到2‑溴‑5‑氟三氟甲苯;本发明收率达到91.1%以上;反应转化率大于99%,选择性92‑95%;反应过程中应用的原料方便购得,生产成本低,反应过程中得到的废酸可以循环使用,后处理简单,整体工艺没有产生大量含盐和有机物废水;具有非常好的经济效益和社会效益.

专利信息

专利号:US-7205300-B2
优先权日:1997-12-31
标 题:Aryl fused azapolycyclic compounds
发明人：COE JOTHAM WADSWORTH; BROOKS PAIGE ROANNE PALMER
权利人:PFIZER
摘要:This invention is directed to compounds of the formula (I): n nand their pharmaceutically acceptable salts, wherein R 1 , R 2 , and R 3 are as defined herein; intermediates for the synthesis of such compounds, pharmaceutical compositions containing such compounds; and methods of using such compounds in the treatment of neurological and psychological disorders.