CAS: 63038-27-7; H-Tle-Ome.Hcl

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63038-26-6 167223-43-0 176504-88-4

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CAS号67-56-1 甲醇 | CAS号139163-43-2 (S)-2-氨基-3,3-二甲... | CAS号20859-02-3 L-叔亮氨酸 | CAS号75158-11-1 methyl-4-methox... | CAS号630-19-3 三甲基乙醛 | CAS号33978-37-9 1-[(S)-α-methyl... | CAS号1052703-81-7 N-(3,3-二甲基丁基)-3... | CAS号402958-96-7 (2S)-2-环己基-N-(2... | CAS号402958-98-9 (1S,3AR,6AS)-(2... | CAS号144054-70-6 (S)-(-)-2-氨基-3,... | CAS号112245-13-3 (S)-叔亮氨醇 | CAS号1206524-85-7 (33R,35S,91R,92... | CAS号1350514-68-9 格拉瑞韦

1-<(S)-α-Methylbenzylimino>-2,2-Dimethylpropane置于palladium On Activated Charcoal Sodium Hydroxide,氯化亚砜,硫酸,氢气,Manganese(Ll) Chloride,Leucine Aminopeptidase体系中,用 甲醇,乙醇,水,溶剂黄146 作为反应溶剂,25.0~40.0 °C,101.33 Kpa 条件下,反应 60.0H,反应生成 L-叔亮氨酸甲酯盐酸盐
参考文献:[d-丙氨酸2,叔丁基甘氨酸5]脑啡肽酰胺的合成,酶降解,亲脂性和生物活性†
标题:[d-丙氨酸2,叔丁基甘氨酸5]脑啡肽酰胺的合成,酶降解,亲脂性和生物活性†
摘要:L-ç α-吨-Butylglycine(错误),其酰胺,甲基酯,和ñ α-吨丁氧基羰基衍生物,通过不对称合成制备,并且所述的hansch侧链的疏水性(亲脂性)参数来确定.一个新的脑啡肽类似物,H.酪氨酸-D丙氨酸-甘氨酸-苯丙氨酸-错误.nh 2的合成这是在2药理学活性的体外测定法和对许多酶的抗强烈体外.
DOI:10.1002/hlca.19800630410

专利信息

专利号:US-8461107-B2
优先权日:2008-04-28
标题:HCV NS3 protease inhibitors
发明人：LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; GILBERT KEVIN F; MCINTYRE CHARLES J; RUDD MICHAEL T
权利人:LIVERTON NIGEL J; MCCAULEY JOHN A; BUTCHER JOHN W; GILBERT KEVIN F; MCINTYRE CHARLES J; RUDD MICHAEL T; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:US-8216999-B2
优先权日:2005-07-20
标题 :HCV NS3 protease inhibitors
发明人：HOLLOWAY M KATHARINE; LIVERTON NIGEL J; LUDMERER STEVEN W; MCCAULEY JOHN A; OLSEN DAVID B; RUDD MICHAEL T; VACCA JOSEPH P; MCINTYRE CHARLES J
权利人:HOLLOWAY M KATHARINE; LIVERTON NIGEL J; LUDMERER STEVEN W; MCCAULEY JOHN A; OLSEN DAVID B; RUDD MICHAEL T; VACCA JOSEPH P; MCINTYRE CHARLES J; MERCK SHARP & DOHME
摘要:The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:US-2013178413-A1
优先权日:2010-09-21
标题 :Hcv ns3 protease inhibitors
发明人：MCCAULEY JOHN A; LIVERTON NIGEL J; RUDD MICHAEL T; GILBERT KEVIN F; FERRARA MARCO; SUMMA VINCENZO; CRESCENZI BENEDETTA
权利人:MCCAULEY JOHN A; LIVERTON NIGEL J; RUDD MICHAEL T; GILBERT KEVIN F; FERRARA MARCO; SUMMA VINCENZO; CRESCENZI BENEDETTA
摘要:The present invention relates to macrocyclic compounds of formula I that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use for treating or preventing HCV infections.

专利号:CN-116082175-A
优先权日:2022-12-29
标 题:Rapid synthesis method of chiral arylamine compound without metal catalytic axis