CAS: 530-64-3; Quinoline Hydrochloride

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CAS号91-22-5 喹啉 | CAS号14221-01-3 四(三苯基膦)钯(0) | CAS号98-88-4 苯甲酰氯 | CAS号75-36-5 乙酰氯 | CAS号38148-24-2 quinoline, salt... | CAS号79-43-6 二氯乙酸 | CAS号7647-01-0 盐酸 | CAS号941-87-7 1(2H)-Quinoline... | CAS号22598-39-6 1-chlorosulfiny... | CAS号635-46-1 1,2,3,4-四氢喹啉 | CAS号1309450-24-5 2-(1-methyl-1H-... | CAS号91-22-5 喹啉 | CAS号109-69-3 1-氯丁烷 | CAS号5332-24-1 3-溴喹啉 | CAS号69268-39-9 3,6-二溴喹啉 | CAS号16032-40-9 2-(4-甲氧基苯基)-喹啉 | CAS号60-09-3 4-阿基苯甲酯

喹啉置于盐酸体系中,用 1,4-二氧六环,二氯甲烷 作为反应溶剂,化学反应生成 盐酸喹啉
参考文献:氮杂芳烃的电子转移协同亲核氟化:喹啉的选择性 C-H 氟化
标题:氮杂芳烃的电子转移协同亲核氟化:喹啉的选择性 C-H 氟化
摘要:直接c-H氟化是构建芳香族c-F键的有效策略,但在其他官能团存在的情况下特定c-H键的断裂以及c-F键形成的高势垒使得转化具有挑战性.芳烃亲电氟化的进展已有报道,但由于相应的 Wheland 中间体的高能量,缺电子氮杂芳烃的类似转化仍然难以实现.由于氟化物攻击后迈森海默中间体的特性,缺电子氮杂芳烃的亲核氟化是困难的,其中氟化物消除以再生底物比氢化物消除形成产物更有利.在此,我们报告了一种新概念,即通过异步协同 F--E--H +转移的链式过程,不形成氮杂芳烃 Meisenheimer 中间体的 C-h 亲核氟化.协调一致的亲核芳族取代策略使得喹啉首次成功发生亲核氧化氟化.
DOI:10.1021/jacs.3C07119

专利信息

专利号:US-6235957-B1
优先权日:1998-06-29
标 题 :Process for the preparation of cyclopropylacetylene
发明人：CHOUDHURY ANUSUYA
权利人:DU PONT PHARM CO
摘要:The present invention relates generally to novel methods for the synthesis of cyclopropylacetylene which is an essential reagent in the asymmetric synthesis of (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one; a useful human immunodeficiency virus (HIV) reverse transcriptase inhibitor.

专利号:US-4154962-A
优先权日:1975-01-21
标题:Synthesis of hydratropic acid and some of its alkyl derivatives
发明人：BAIOCCHI LEANDRO
权利人:AZIENDE CHIMICHE RUINITE FRANC
摘要:A new process by which cyclohexanone is treated, in the presence of a suitable acid or a salt of an organic base, with pyruvic acid or with one of its simple derivatives (ester or salt) to give hydratropic acid.

专利号:US-4096177-A
优先权日:1974-04-11
标题:Process for the preparation of p. isobutyl-hydratropic
发明人：BAIOCCHI LEANDRO
权利人:BAIOCCHI LEANDRO
摘要:A process for the synthesis of Ibuprofen, p - isobutyl hydrotropic acid is described based upon the aromatization reaction which takes place when a dialkyl alpha -acetyl- alpha -[(5-methyl-3-oxo)-hexyl]- alpha '-methyl-succinate (II) is heated at temperatures of about 200 DEG with a strong acid, or a salt of a strong acid with an organic base.

专利号:US-3579544-A
优先权日:1967-05-24
标题 :Total process for making 13-hydrocarbon substituted gonapolyene - 17 - one compounds and intermediates produced in the course of the process
发明人：HIRAGA KENTARO; ASAKO TSUNEHIKO; MIKI TAKUICHI
权利人:TAKEDA CHEMICAL INDUSTRIES LTD
摘要:A COMPOUND HAVING A 16-(ETHERIFIED OR ESTERIFIED HYDROXY)-17-ACYLOXY-13-SUBSTITUTED GONA-1,3,5(10),8,14PENTAENE NUCLEUS IS OBTAINED BY ALLOWING A COMPOUND HAVING A 17-ACYLOXY-13-SUBSTITUTED 8,14-SECOGONA-1,3,5 (10),9(11),15-PENTAENE-14-ONE NUCLEUS TO CONTACT WITH AN ACID CATALYST IN PRESENCE OF ALCOHOL, PHENOL OR FATTY ACID, AND CONVERTING THE RESULTANT COMPOUND HAVING A 16-(ETHERIFIED OR ESTERIFIED HYDROXY)-17-ACYLOXY-13-SUBSTITUTED GONA-1,3,5(10),8,14-PENTAENE NUCEUS DIRECTLY OR AFTER REDUCTION OF ITS DOUBLE BOND AT THE 8-POSITION OR BANDS AT THE 8- AND 14-POSITIONS, TO A COMPOUND HAVING A 13-(HYDROCARBON SUBSTITUTED)GONAPOLYEN-17-ONE NUCLEUS. IT IS THUS MADE POSSIBLE TO EFFECT THE TOTAL SYNTHESIS OF THE GONA POLYENES (E.G. ESTRONE) VIA A LESSER NUMBER OF STEPS THAN HAS HERETOFORE BEEN POSSIBLE.

专利号:US-9889128-B2
优先权日:2014-09-17
标题 :Method for producing benzazoloquinolium (BQs) salts and using the biological activity of the composition
发明人：COX OSVALDO; ZAYAS BEATRIZ
权利人:SISTEMA UNIV ANA G MENDEZ INC
摘要:Disclosed is the synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds. The compounds are further used as markers due to their fluorescent properties including in hypoxic environments. n This disclosure further describes anti-cancer screening of two BQS, namely, 7-benzyl-3-aminobenzimidazo[3,2-a]quinolinium chloride (ABQ-48: NSC D-763307) and the corresponding 7-benzyl-3-nitrobenzimidazo[3,2-a]quinolinium chloride (NBQ 48: NSC D-763303).

专利号:US-9085574-B2
优先权日:2009-04-01
标 题 :Method for producing benzazoloquinolium (BQs) salts, using the composition as cellular markers, and using the biological activity of the composition
发明人：ZAYAS BEATRIZ; COX OSVALDO
权利人:ZAYAS BEATRIZ; COX OSVALDO
摘要:A synthesis procedure for benzazolo[3,2-a]quinolinium chloride salts and the inclusion of chloro-substituent, amino-substituent, and nitro-substituent resulting in several compounds wherein said procedures provides an increment in the compounds biological activity. The compounds are further used for intra cellular binding, cytotoxicity on malignant cells through apoptosis activation mediated by mitochondrial damage, cellular organelles binding and damage, DNA fragmentation, marker of bacterial growth, antibacterial activity, cell cycle disruption, and a marker due to the auto-fluorescent properties.