专利号:WO-2012088402-A1 优先权日:2010-12-22 标题 :Synthesis of conolidine and discovery of a potent non-opioid analgesic for pain 发明人:BOHN LAURA M; MICALIZIO GLENN C 权利人:SCRIPPS RESEARCH INST; BOHN LAURA M; MICALIZIO GLENN C 摘要:The first de novo synthetic pathway to the exceptionally rare C5-nor stemmadenine natural product, conolidine, and the first asymmetric synthesis of any member of this natural product class arc described. C5-nor stemmadenine compositions are also described. These compounds, for example,(+/- )-,(+)- and (-)-conolidine are potent and efficacious non-opioid analgesics in tonic and persistent pain.
专利号:US-7700783-B2 优先权日:2003-10-09 标题 :Synthesis of discodermolide and variants thereof 发明人:SMITH III AMOS B; FREEZE BRIAN SCOTT; XIAN MING 权利人:UNIV PENNSYLVANIA 摘要:Processes for synthesizing a compound of Formula (I) are provided by reacting a compound of Formula (i) with a compound of Formula (xx).
专利号:US-2005209355-A1 优先权日:2004-03-22 标 题:[Novel Reactions and the Products of Such Reactions] 发明人:ROITMAN LIPA L 权利人:ROITMAN LIPA L 摘要:A process for the synthesis of novel compounds is described comprising reacting tetrachloroethylene with substances containing active methylene group in the presence of free radical initiators. Also, a process for grafting tetrachloroethylene is described comprising reacting these compounds with polymers containing active methylene group in the presence of free radical initiators. Furthermore, a method of conducting such reactions to high conversion is described, comprising conducting the reactions in the reflux condensate. The present invention provides a novel and high yield route for heretofore unobtainable materials.
专利号:US-5922335-A 优先权日:1995-05-15 标 题:Uses for ascorbyl-phosphoryl-cholesterol in topical compositions 发明人:PTCHELINTSEV DMITRI 权利人:AVON PROD INC 摘要:Novel uses of 3'-(L-ascorbyl-2-o-phosphoryl)-cholesterol, 3'-(L-ascorbyl-3-o-phosphoryl)-cholesterol, structural or functional isomers thereof and salts thereof (referred to collectively as 'APC compounds') are disclosed. Such novel uses include a method of reducing epidermal synthesis of abnormal elastin, especially epidermal synthesis of abnormal elastin that results from exposure to UV radiation. Also disclosed is a novel method of stimulating keratinocyte formation of triglycerides. In addition, a novel method of achieving antioxidant activity, both in the skin and also in topical compositions, is disclosed.
专利号:US-11866443-B2 优先权日:2017-05-19 标 题:Method for separating optically active hydroxy cineole derivatives 发明人:DITRICH KLAUS; RACK MICHAEL; BENSON STEFAN; GOETZ ROLAND; KRAUS HELMUT 权利人:BASF AGRO BV 摘要:The present invention relates to a method for separating an optically active hydroxy cineole derivatives by lixiviation and crystallization and enantiomerically pure optically active hydroxy cineole derivatives of purity greater than 99.5% that have been prepared by this process. The present invention further relates to use of the desired enantiomer having enantiomeric excess of at least 99.5% ee as prepared according to the present invention, for the synthesis of enantiomerically pure 7-oxabicyclo[2.2.1]heptane derivatives.
专利号:US-11596930-B2 优先权日:2020-04-08 标 题 :Nickel/titanium oxide-silicon oxide catalyst for synthesizing terpinene-4-ol, preparation method thereof, and method of synthesizing terpinene-4-ol using the same 发明人:ZHENG HUIDONG; WU DAN; CHEN JINGJING; LIU JIE; WU NAIXIN 权利人:UNIV FUZHOU 摘要:The present invention discloses a nickel/titanium oxide-silicon oxide catalyst for synthesizing terpinene-4-ol as well as a preparation method and method of synthesizing terpinene-4-ol using the same. The preparation method includes the steps of catalyst preparation, terpinene-4-ol synthesis and the like are disclosed in the present invention. The preparation method includes the following steps: firstly, preparing a mixed colloid of TiO2 and SiO2 by using a sol-gel method, and then centrifuging, washing, drying and roasting is performed to prepare a TiO2—SiO2 binary oxide; then, preparing Ni/TiO2-SiO2 by dipping in a nickel nitrate solution, and preparing a supported catalyst by drying and roasting; and finally, adopting a terpinolene-4, 8-epoxide a raw material, carrying out isomerization under the dual catalytic action of TiO2-SiO2 and Ni of the supported catalyst, and carrying out hydrogenation to prepare terpinene-4-ol. The preparation method can combine isomerization and hydrogenation reaction on the same catalyst, has good selectivity on terpinene-4-ol, and is simple to operate and high in product yield.
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