CAS: 40093-94-5; 4-Amino-1-((2S,4R,5S)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidin-2(1H)-One

上下游产品

3',5'-dibenzoyl-2'-deoxy-β-L-uridine 2'-Deoxycytidine 2'-Deoxycytidine 5'-O-(dimethoxytrityl)-4-N-benzoyl-2'-deoxy-L-cytidine

📜3',5'-Dibenzoyl-2'-Deoxy-β-L-Uridine置于ammonium Hydroxide,氨,4-氯苯基二氯磷酸酯体系中,用 1,4-二氧六环,吡啶 作为反应溶剂,化学反应 22.0H,反应生成 4-氨基-1-(2-脱氧-Beta-L-赤式-呋喃戊糖基)-2(1H)-嘧啶酮
参考文献:The Synthesis Of 2'-Deoxy-L-Cytidine-3'-Phosphate
标题:The Synthesis Of 2'-Deoxy-L-Cytidine-3'-Phosphate
摘要:Improvements In The Synthesis Of 2'-Deoxy-L-Cytidine-3'-Phosphate From L-Arabinose Are Described.
DOI:10.1080/07328319808004314

专利信息

专利号:US-11858953-B2
优先权日:2018-04-04
标 题:Compositions and methods for synthesis of phosphorylated molecules
发明人：CHAPUT JOHN; LIAO JEN-YU; BALA SAIKAT
权利人:UNIV CALIFORNIA
摘要:The invention provides compositions and methods for synthesis of phosphorylated organic compounds, including nucleoside triphosphates.

专利号:US-7582748-B2
优先权日:2003-03-20
标题:Methods of manufacture of 2′-deoxy-β-L-nucleosides
发明人：RABI JAIME A
权利人:MICROBIOL QUIMICA FARMACEUTICA
摘要:The present invention relates to the synthesis of 2′-deoxy-β-L-thymidine, 2′-deoxy-β-L-uridine and 2′-deoxy-β-L-cytidine, and their derivatives, such as the 3′-O-acyl or 3′,5′-O-diacyl prodrugs, including the 3′-O-L-aminoacyl and 3′,5′-O-L-diaminoacyl prodrugs, and particularly the 3′-O-L-valinyl and 3′,5′-O-L-divalinyl prodrugs.

专利号:US-7595390-B2
优先权日:2003-04-28
标 题:Industrially scalable nucleoside synthesis
发明人：MOUSSA ADEL; WANG JING YANG; STORER RICHARD
权利人:NOVARTIS AG
摘要:An industrially scalable two-step process for preparing a β-L-2′-deoxy-nucleoside that results in a predominance of the β- over the α-anomeric form of the compound is described. An optional third step may be used to prepare 3′-prodrugs of desirable β-L-2′-deoxy-nucleosides for the delivery of these pharmaceuticals effective for treating viral diseases. The synthetic process is applicable in particular to the formation of β-L-2′-deoxy-cytidine, a pharmaceutically acceptable salt or prodrug thereof. The process can provide a relatively uncontaminated product that may require no further isolation or purification, thereby making the synthesis easily scalable for industrial manufacture.

专利号:US-2020239500-A1
优先权日:2018-04-04
标 题 :Compositions and Methods for Synthesis of Phosphorylated Molecules

专利号:US-6582953-B2
优先权日:1999-04-14
标 题 :Organ chamber for exsanguinous metabolic support system
发明人：BRASILE LAUREN
权利人:BREONICS INC
摘要:An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed. The system employs an organ chamber comprising a container and a support member adapted to inhibit movement of the organ within the container during perfusion and/or transport. The organ chamber additionally comprises a conduit for receiving venous outflow of perfusion solution and preventing its contact with the outer surfaces of the organ. A conduit for receiving organ product enables the collection of organ product from a functional organ during perfusion. Use of the organ chamber supports de novo or continued synthesis of constituents necessary for long-term maintenance of organs for transplantation, for resuscitation and active repair of organs that have sustained warm ischemic damage, and for transportation of isolated organs is also disclosed.

专利号:JP-2003513984-A
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleoside