CAS: 298-46-4; 5H-Dibenzo[b,F]Azepine-5-Carboxamide

上下游产品

CAS号256-96-2 亚氨基芪 | CAS号917-61-3 氰酸钠 | CAS号1189-71-5 氯磺酰异氰酸酯 | CAS号42787-75-7 5-氰基-5H-二苯并[b,f]氮杂卓 | CAS号590-28-3 氰酸钾 | CAS号7722-84-1 过氧化氢 | CAS号420-05-3 正氰酸 | CAS号33948-22-0 亚氨基芪甲酰氯 | CAS号506-89-8 尿素盐酸盐 | CAS号59690-99-2 trans-10,11-dib... | CAS号3564-73-6 双氢卡马西平 | CAS号42787-75-7 5-氰基-5H-二苯并[b,f]氮杂卓 | CAS号36507-30-9 卡马西平 10,11-环氧化物 | CAS号35079-97-1 10,11-Dihydro-1... | CAS号52618-28-7 carbamazepine c... | CAS号144-62-7 草酸 | CAS号118-92-3 邻氨基苯甲酸 | CAS号298-12-4 乙醛酸 | CAS号28721-07-5 奥卡西平

5-氰基-5H-二苯并[b,F]氮杂卓置于硫酸,溶剂黄146体系中,用 Ice-Water 用作溶剂,化学反应生成卡马西平
参考文献:Process For The Production Of 5-Cyano-And
标题:Process For The Production Of 5-Cyano-And
摘要:该发明涉及一种新颖且技术先进的方法,通过在强极性物质存在下,将5H-二苯并[b,F]氮杂环庚烷与卤氰试剂反应制备5-氰基-5H-二苯并[b,F]氮杂环庚烷.5-氰基-5H-二苯并[b,F]氮杂环庚烷可用作制备5-羰基-10(11)-氧代-10,11-二氢-5H-二苯并[b,F]氮杂环庚烷的起始物质,该物质已知具有抑制中枢,抗抽搐和中枢肌肉松弛活性.

专利信息

专利号:US-12264143-B2
优先权日:2020-12-17
标 题:Synthesis of cannabinoids and cannabinoid precursors, and related compounds, formulations, and methods of use
发明人：SAMMIS GLENN M; ROGGEN MARKUS
权利人:NALU BIO INC
摘要:Methods are provided for the synthesis of cannabinoids, including cannabidiol (CBD), cannabinol (CBN), cannabichromene (CBC), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannabidivarin (CBDV), cannabidibutol (CBD-C4), dihydrocannabidiol (DCBD), tetrahydrocannabivarin (THCV), analogs thereof, and precursors to the foregoing. One method employs phloroglucinol or a phloroglucinol analog as a starting material. The syntheses are stereospecific, efficient, selective, and cost-effective, with little or no potential for generation of THC ((−)-trans-Δ9-tetrahydro-cannabinol) or any other psychoactive side product. Telescoped syntheses are also provided, as are new cannabinoids, pharmaceutical formulations, and methods of use.

专利号:US-9868752-B2
优先权日:2012-04-13
标题 :Modular assembly of metal-organic super-containers incorporating calixarenes
发明人：WANG ZHENQIANG; Dai feng-rong
权利人:UNIV OF SOUTH DAKOTA; SOUTH DAKOTA BOARD OF REGENTS
摘要:A new strategy to design container molecules is presented. Sulfonylcalix[4]arenes, which are synthetic macrocyclic containers, are used as building blocks that are combined with various metal ions and tricarboxylate ligands to construct metal-organic ‘super-containers’ (MOSCs). These MOSCs possess both endo and exo cavities and thus mimic the structure of viruses. The synthesis of MOSCs is highly modular, robust, and predictable.

专利号:US-12234200-B2
优先权日:2019-04-16
标 题:Synthetic methods of preparing esketamine
发明人：CHEN CHENG YI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to methods for the asymmetric synthesis of esketamine. The present invention is further directed to key intermediates in the asymmetric esketamine synthesis. In one embodiment, the invention is an asymmetric synthesis of esketamine comprising the conversion of (S)-2′-chloro-2-methoxy-3,4,5,6-5 tetrahydro-[1, 1′-biphenyl]-3-yl carbamate to (S)-2′-chloro-1-isocyanato-6-methoxy-1,2,3,4-tetrahydro-1,1′-biphenyl.

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-2022233673-A1
优先权日:2019-06-04
标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
发明人：BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

专利号:WO-2016111658-A1
优先权日:2015-01-07
标 题:Synthesis of thiosemicarbazone derivatives comprising sulphonamide group with potential anticonvulsant activity
发明人：IYIDOGAN AYSEGUL; EMRE EMINE ELCIN; TOPALFAKIOGÄžLU RAHIME BETÃœL; KAYMAKÇIOÄžLU BEDIA; ARICIOÄžLU FEYZA
权利人:IYIDOGAN AYSEGUL; EMRE EMINE ELCIN
摘要:The present invention relates to the synthesis method of thiosemicarbazone derivatives comprising sulphonamide group and having high anticonvulsant/antiepileptic activity.