CAS: 23930-37-2; 2-((3R,5S,8S,9S,10S,13S,14S,17S)-3-Hydroxy-10,13-Dimethyl-11-Oxohexadecahydro-1H-Cyclopenta[a]Phenanthren-17-yl)-2-Oxoethyl Acetate

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    阿法多龙 Alphadolone 14107-37-0

    合成工艺路线路线简述

      📜阿法多龙 以52的收率获得3Alpha,21-二羟基-5Alpha-孕甾烷-11,20-二酮 21-乙酸酯
      参考文献:J. Org. Chem. 1972,37,3990-3996
      标题:J. Org. Chem. 1972,37,3990-3996

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      专利信息


      专利号:US-2006052356-A1
      优先权日:2004-09-03
      标 题:Pharmacological methods to modulate oxygen consumption
      发明人:WARD KEVIN R; BARBEE R W; REYNOLDS PENNY; DIEGLEMANN ROBERT; KUKREJA RAKESH; SPIESS BRUCE; EVANS MELISSA; EDWARDS ERIC
      权利人:WARD KEVIN R; BARBEE R W; REYNOLDS PENNY; DIEGLEMANN ROBERT; KUKREJA RAKESH; SPIESS BRUCE; EVANS MELISSA; EDWARDS ERIC
      摘要:Methods of modulating oxygen consumption in tissues are provided. In particular, the methods involve the administration of agents that transiently inhibit protein synthesis. The methods are used to treat ischemia and reperfusion-related injuries by temporarily decreasing oxygen consumption needs, and/or by inhibiting inflammation that results from reperfusion.

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      ✅ COA系统入驻 | 共享模式

      主要参考文献


      1: Nadeson R, Goodchild CS. Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically. Br J Anaesth. 2001 May;86(5):704-8. Danish.

      合成参考文献


      摘要:Proceedings of the European Society of Toxicology., 16(208), 1975
      摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2003).
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