CAS: 197010-20-1; 2-((1-Benzylpiperidin-4-yl)(Hydroxy)Methyl)-5,6-Dimethoxy-2,3-Dihydro-1H-Inden-1-One

上下游产品

1-benzyl-4-(5,6-dimethoxy-1-oxo-indane-2-carbonyl)-pyridinium chloride donepezil piperidine1-benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylidenyl)methylpiperidine

多奈哌齐杂质置于platinum On Activated Charcoal 氢气,碳酸氢钠体系中,用 甲醇,水 用作溶剂,20.0 °C,600.01 Kpa 条件下,反应生成羟基多萘哌齐
参考文献:Wo2007/15052
标题:Wo2007/15052

专利信息

专利号:US-2009253746-A1
优先权日:2005-11-14
标题 :Synthesis and Preparations of Intermediates and New Polymorphs Thereof Useful For The Preparation Of Donepezil Hydrochlcoride
发明人：SOLDEVILLA MADRID NURIA
权利人:SOLDEVILLA MADRID NURIA
摘要:The invention relates to an improved process for preparing 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyin-dan- 1 -one (a key intermediate in the synthesis of donepezil hydrochloride), crystalline polymorph forms of this key intermediate and their use thereof for producing donepezil hydrochloride. In particular, the invention provides an improved method for producing the intermediate 2-(1-benzylpiperidin-4-ylmethyliden)-5,6-dimethoxyindan-1-one. The process includes reacting 5,6-dimethoxyin-dan- 1 -one with 1-benzylpiperidine-4-carbaldehyde using potassium hydroxide in an aqueous solvent. The aqueous solvent can be a mixture of an organic solvent and water Where the organic solvent is not miscible with water, the reaction may be performed in the presence of a phase transfer catalyst.

专利号:US-2009298879-A1
优先权日:2006-05-18
标 题 :Impurities of Donepezil
发明人：KRIZMANIC IRENA; LERMAN LIDIJA; SAMARDZIC ZRINKA; KACZOROWSKA KATARZYNA; MANIKOWSKI ANDRZEJ; ZIORO BARBARA; GREBENAR IVICA; KORUZNJAK JASNA DOGAN
权利人:PLIVA HRVATSKA D O O
摘要:The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a pharmaceutically-acceptable salt thereof, and to methods of identifying such impurities. The invention also relates to the use of these impurities in analytical techniques and to product that contain certain low levels of these impurities in particular the following impurities are disclosed: formula (I) and formula (II).

专利号:EP-1960357-A2
优先权日:2005-11-14
标 题 :Synthesis and preparations of intermediates and polymorphs thereof useful for the preparation of donepezil hydrochloride

专利号:CA-2629720-A1
优先权日:2005-11-14
标 题:Synthesis and preparations of intermediates and polymorphs thereof useful for the preparation of donepezil hydrochloride

专利号:JP-2009515945-A
优先权日:2005-11-14
标题 :Improved synthesis and preparation of intermediates and novel polymorphs useful for the preparation of donepezil hydrochloride

专利号:WO-2007119118-A2
优先权日:2005-11-14
标题 :Synthesis and preparations of intermediates and polymorphs thereof useful for the preparation of donepezil hydrochloride