CAS: 124932-43-0; (R)-Azepan-3-Amine

上下游产品

(R)-α-amino-ε-caprolactam hydr°Chloride 3-aminoazepan-2-one (R)-3-amino-azepan-2-one (R)-3-tert-butyloxycarbonylamino-1H-azacycloheptane 1-tert-butoxycarbonyl-3-amino-hexahydroazepine

(R)-3-氨基-2-己内酰胺置于lithium Aluminium Tetrahydride体系中,用 四氢呋喃 用作溶剂,化学反应生成(R)-3-氨基-六氢-1H-氮杂环庚烷
参考文献: Compounds And Compositions For Modulating Egfr Activity[fr] Composés Et Compositions Destinés à La Modulation De L'Activité De L'Egfr
标题: Compounds And Compositions For Modulating Egfr Activity[fr] Composés Et Compositions Destinés à La Modulation De L'Activité De L'Egfr
摘要:这项发明提供了化合物及其药物组合物,用于调节egfr活性,以及使用这些化合物治疗,改善或预防与异常或失调的egfr活性相关的疾病的方法.

专利信息

专利号:US-8252783-B2
优先权日:2007-01-24
标 题:Quinolone carboxylic acids, derivatives thereof, and methods of making and using same
发明人：HARMS ARTHUR E; ARUL RAMAKRISHNAN; SONI ANIL K
权利人:HARMS ARTHUR E; ARUL RAMAKRISHNAN; SONI ANIL K; BAUSCH & LOMB
摘要:A process of preparing a quinolone carboxylic acid or its derivatives having Formula I, Ia, Ib, or IV, as shown herein, comprises using a starting quinolone that already has one or more desired substituents at one or more particular positions on the quinolone ring and preserving the orientation of such substituents throughout the synthesis. The present process comprises fewer steps than prior-art processes. The present process also can include a simple separation of a desired enantiomer of the quinolone carboxylic acid or its derivatives from the enantiomeric mixture. Pharmaceutical compositions comprising fluoroquinolones prepared by the present process can be used effectively against a variety of microbial pathogens.