📜2,6-二甲基吡啶,1-Bromoethanol置于trifluoromethanesulfonic Acid Anhydride体系中,用 二氯甲烷 用作溶剂,以72%的收率获得三氟甲磺酸2-溴-乙酯 参考文献:Chelating Compounds,Their Complexes With Paramagnetic Metals 标题:Chelating Compounds,Their Complexes With Paramagnetic Metals 摘要:能够螯合双价和三价顺磁性金属离子的化合物,所述金属离子的螯合配合物以及生理上相容的盐,以及它们在"磁共振成像"(M.R.I.)技术中作为对比剂的使用.
专利信息
专利号:US-7517895-B2 优先权日:2001-08-24 标题 :Synthetic diazonamides 发明人:HARRAN PATRICK G; LI JING; JEONG SUSAN 权利人:UNIV TEXAS 摘要:The application discloses novel synthetic compounds, modeled after unique toxins extracted from the marine invertebrate Diazona angulata useful in the treatment abnormal cell mitosis. The application also discloses novel methods for synthesis of these compounds and methods of using these compounds.
专利号:US-8071785-B2 优先权日:2006-06-09 标题:Synthesis and evaluation of 18F-labelled-alkyl-1-[(1R)-1-phenylethyl]-1H-imidazole-5-carboxylate as a tracer for the quantification of β-11-hydroxylase enzyme in the adrenal glands 发明人:LANGSTROM BENGT; KARIMI FARHAD; BLOM ELISABETH; ERLANDSSON MARIA 权利人:LANGSTROM BENGT; KARIMI FARHAD; BLOM ELISABETH; ERLANDSSON MARIA; GE HEALTHCARE LTD 摘要:Radioactively labeled derivatives of (R)-3-(1-phenylethyl)-3H-imidazole-4-carboxylic acid esters and one-step methods for preparing these compounds are provided. The radioactively labelled compounds, and pharmaceutical acceptable salts and solvates are useful as radiopharmaceuticals, especially for use in Positron Emission Tomography (PET) for the diagnosis of adrenal cortical masses such as incidentaloma, adenoma, primary and metastatic cortical carcinoma. Associated kits and method for PET studies are also provided.
专利号:US-7754188-B2 优先权日:2003-06-30 标 题:Radiolabeled cannabinoid-1 receptor modulators 发明人:BURNS H DONALD; CHEN ALEX M; GIBSON RAYMOND E; GOULET MARK T; HAGMANN WILLIAM K; HAMILL TERENCE G; JEWELL JAMES P; LIN LINUS S; LIU PING; PERESYPKIN ANDREY V 权利人:MERCK SHARP & DOHME 摘要:The present invention relates to particular radiolabeled Cannabinoid-1 (CB1) receptor modulators, and methods of using these modulators for labeling and diagnostic imaging of Cannabinoid-1 receptors in mammals, particularly humans. In addition, intermediates useful for the synthesis of the radiolabeled Cannabinoid-1 receptor modulators are also disclosed, as well as the processes for synthesizing the radiolabeled Cannabinoid-1 receptor modulators. Still further, formulations of the radiolabeled Cannabinoid-1 receptor compounds are described.
专利号:US-7022720-B2 优先权日:2001-08-24 标 题 :Synthetic diazonamides as novel anti-mitotic agents 发明人:HARRAN PATRICK G; LI JING; JEONG SUSAN 权利人:UNIV TEXAS 摘要:The application discloses novel synthetic compounds, modeled after unique toxins extracted from the marine invertebrate Diazona angulata useful in the treatment abnormal cell mitosis. The application also discloses novel methods for synthesis of these compounds and methods of using these compounds.
专利号:US-2009297447-A1 优先权日:2006-06-09 标 题 :Synthesis and evaluation of 18f-labelled-alkyl-1-[(1r)-1-phenylethyl]-1h-imidazole-5-carboxylate as a tracer for the quantification of beta-11-hydroxylase enzyme in the adrenal glands
专利号:WO-2007144725-A2 优先权日:2006-06-09 标 题:SYNTHESIS AND EVALUATION OF 18F-LABELLED ALKYL-1-[(R)-1-PHENYLETHYL]-1H-IMIDAZOLE-5-CARBOXYLATE AS A TRACER FOR THE QUANTIFICATION OF β-11-HYDROXYLASE ENZYME IN THE ADRENAL GLANDS