CAS: 77-41-8; 1,3-Dimethyl-3-Phenylpyrrolidine-2,5-Dione

该化合物是一种化学化合物,其特点是2和5个位置的环状结构,具有两个碳基组(氯酮),具有双亚基环状环状,在室温下一般是白色至非白色的固体,在乙醇和丙酮等有机溶剂中可溶解,其熔点因纯度和形式不同而异.DMAP因其在有机合成中作为试剂和催化剂的作用而闻名,特别是在电动反应中,因此加强了电动反应.二甲基氨基和苯基组的存在有助于其独特的电子特性,使其在各种化学过程中成为有价值的化合物.此外,由于DMAP可能具有毒性和刺激性,因此必须谨慎地处理它.在实验室环境中与该物质打交道时,应注意适当的安全措施.

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上下游产品

CAS号14231-67-5 (+/-)-2-Methyl-... | CAS号74-89-5 氨基甲烷 | CAS号39122-23-1 (3S)-1,3-dimeth...

合成工艺路线路线简述

  • 合成目标产物 Methsuximide 主要起始原料 Alpha-Methyl-Alpha-Phenylsuccinimide And Iodomethane
  • (文献来源)合成步骤主要原料 Alpha-Methyl-Alpha-Phenylsuccinimide 和 Iodomethane
📜在 Palladium On Activated Charcoal,2,9-二甲基-4,7二苯基-1,10-菲啰啉,氢气,氧气,Copper (I) Acetate,Potassium Carbonate体系中,用 丙酮,甲苯 作为反应溶剂,80.0 °C,101.33 Kpa 条件下,反应生成 甲琥胺
参考文献:通过未活化的 C[双键,长度为 M-破折号]C 键断裂,铜催化烯烃束缚酰胺与 O2 的氧化:环状酰亚胺的直接方法.
标题:通过未活化的 C[双键,长度为 M-破折号]C 键断裂,铜催化烯烃束缚酰胺与 O2 的氧化:环状酰亚胺的直接方法.
摘要:未活化烯烃通过 C[双键,长度为 M-Dash]C 键双断裂的转化总是很有吸引力但非常具有挑战性.我们在此报告了一种化学选择性方法,通过未活化的 C[双键,长度为 M-Dash]C 键的新型 Cu 催化的偕氨基氧化来制备有价值的环状酰亚胺.o2成功地用作氧化剂和o源,并通过c[双键,长度为m-Dash]C键断裂结合到烯基酰胺中,用于有效制备琥珀酰亚胺或戊二酰亚胺衍生物.此外,该策略在简单条件下可用于生物活性化合物的后期修饰和药物合成,显示出潜在的应用前景.
DOI:10.1039/c9Sc03175H

海关参考信息

专利信息


专利号:US-2008214827-A1
优先权日:2004-02-03
标 题:Synthesis of Cyanoimino-Benzoimidazoles
发明人:GOEHRING R RICHARD; WHITEHEAD JOHN; SHAO BIN
权利人:EURO CELTIQUE SA
摘要:Disclosed in certain embodiments is a process for synthesizing a compound of formula (V) and salts thereof.

专利号:CA-2555219-A1
优先权日:2004-02-03
标 题 :Synthesis of cyanoimino-benzoimidazoles

专利号:US-8945508-B2
优先权日:2009-10-13
标 题 :Dendrimer compositions and methods of synthesis
发明人:BAKER JR JAMES R; HUANG BAOHUA
权利人:BAKER JR JAMES R; HUANG BAOHUA; UNIV MICHIGAN
摘要:The present invention relates to novel dendrimer compounds and methods of synthesizing the same. In particular, the present invention is directed to novel polyamidoamine (PAMAM) dendrimers, novel dendrimer branching units, methods for synthesizing such novel PAMAM dendrimers and functionalized dendrimers, as well as systems and methods utilizing the dendrimers (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease diagnosis and/or therapy, etc.))).

专利号:WO-2005075459-A1
优先权日:2004-02-03
标题:Synthesis of cyanoimino-benzoimidazoles

专利号:MX-2009002267-A
优先权日:2006-08-28
标题:PROCEDURE AND INTERMEDIARIES FOR THE SYNTHESIS OF DERIVATIVES AND INTERMEDIARIES OF (3-ALQUIL-5-PIPERIDIN-1-IL-3,3A-DIHIDRO-PIRAZOLO [1,5-A] PIRIMIDIN-7-IL) -AMINO.

专利号:US-2013030282-A1
优先权日:2011-07-18
标题:Synthesis and characterization of near ir fluorescent magnetic and non-magnetic albumin nanoparticles for biomedical applications
发明人:MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
权利人:UNIV BAR ILAN; MARGEL SHLOMO; COHEN SARIT; SALKMON ENAV COREM; PELLACH MICHAL
摘要:The present invention discloses Near Infrared (NIR) fluorescent albumin nanoparticles having a structure selected from a core structure or a core-shell structure. Also disclosed are a process of preparing these NIR fluorescent albumin nanoparticles, and a method of in vivo detection of pathologies, in particular cancer pathology, by using administering these NIR fluorescent albumin nanoparticles to a patient.

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✅ COA系统入驻 | 共享模式

主要参考文献


1: Sigler M, Strassburg HM, Boenigk HE. Effective and safe but forgotten: methsuximide in intractable epilepsies in childhood. Seizure. 2001 Mar;10(2):120-4.

合成参考文献


摘要:Journal of Pharmacy and Pharmacology., 6(740), 1954 []
摘要:Browne T et al; Neurology 33 (4): 414-8 (1983)
摘要:Physicians Desk Reference 61st ed, Thomson PDR, Montvale, NJ 2007., p. 2527
摘要:Lewis, R.J. Sr. (ed) Sax's Dangerous Properties of Industrial Materials. 11th Edition. Wiley-Interscience, Wiley & Sons, Inc. Hoboken, NJ. 2004., p. 2474
摘要:Tennison MB, et al; Pediatrics 87 (2): 186-9 (1991)
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