CAS: 7345-82-6; (E)-3-(2,3-Dimethoxyphenyl)Acrylic Acid

上下游产品

malonic acid 2,3-dimethyoxybenzaldehyde (E)-4-(2,3-dimethoxyphenyl)-but-3-en-2-onetrans-cinnamic acid amide2,3-dimethoxy-trans-cinnamic acid amide (E)-ethyl 3-(2,3-dimethoxyphenyl)prop-2-enoate methyl 3-(2,3-dimethoxyphenyl)propenoate (E)-N-(6-Amino-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-3-(2,3-dimethoxy-phenyl)-acrylamide

(E)-4-(2,3-Dimethoxyphenyl)But-3-En-2-One置于copper(L) Iodide,盐酸羟胺,氧气体系中,用 二甲基亚砜 作为反应溶剂,化学反应 12.0H,以51%的收率获得产物2,3-二甲氧基肉桂酸
参考文献:铜催化氧辅助的c(cnoh)-C(烷基)键裂解:芳基/芳烷基/乙烯基酮向芳族酸的便捷转化†
标题:铜催化氧辅助的c(cnoh)-C(烷基)键裂解:芳基/芳烷基/乙烯基酮向芳族酸的便捷转化†
摘要:描述了一种新型的铜催化的芳基/芳烷基/乙烯基酮的需氧氧化c(noh)-C(烷基)键裂解反应,用于合成芳族/丙烯酸.可以选择性地裂解在一端具有芳基/芳烷基/乙烯基而在另一端具有甲基至任何高级烷基的一系列酮,并通过肟中间体将其转化为相应的酸.
DOI:10.1039/c5Ob01569C

专利信息

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-2019271015-A1
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains

专利号:US-10941429-B2
优先权日:2018-01-17
标 题:Enzymatic synthesis of kavalactones and flavokavains

专利号:US-6562844-B2
优先权日:1998-01-23
标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.