CAS: 63200-54-4; 2,4-Dichloro-5H-Pyrrolo[3,2-D]Pyrimidine

相似化合物

1923177-10-9 84905-80-6 1196157-27-3

上下游产品

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6-甲基尿嘧啶置于硫酸,硝酸,溶剂黄146,Sodium Hydroxide,锌体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 21.0H,反应生成 2,4-二氯吡咯[3,2-D]嘧啶
参考文献:一系列 N-5 取代的吡咯并 [3,2-D] 嘧啶作为潜在抗癌药物的结构和生物学研究
标题:一系列 N-5 取代的吡咯并 [3,2-D] 嘧啶作为潜在抗癌药物的结构和生物学研究
摘要:多年来,吡咯并[3,2-D]嘧啶作为潜在的先导化合物被研究用于开发抗增殖剂.大部分焦点都集中在嘧啶环的修饰上,酶识别通常由 C2 和 C4 取代基调节.相比之下,这项工作通过一系列新型 N5 取代的吡咯并 [3,2-D] 嘧啶专注于吡咯环的 N5.针对 Nci-60 人类肿瘤细胞系面板筛选化合物,并使用 Compare 算法分析结果以阐明潜在的作用机制.比较分析返回与已知 Dna 烷化剂和凹槽结合剂的强相关性,证实了这些吡咯并 [3,2-D] 嘧啶充当 Dna 或 Rna 烷化剂的假设.此外,
DOI:10.3390/molecules24142656

专利信息

专利号:US-9895374-B2
优先权日:2015-03-02
标 题:Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof
发明人：RADTKE KATHERINE L; TEMBURNIKAR KARTIK
权利人:UNIV MARYLAND
摘要:The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.

专利号:US-10646490-B2
优先权日:2015-03-02
标 题 :Thieno- and pyrrolopyrimidine analogues and prodrugs thereof as anticancer agents and methods of use thereof
发明人：RADTKE KATHERINE L
权利人:UNIV MARYLAND
摘要:The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds and prodrugs thereof that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.

专利号:CN-112573978-A
优先权日:2019-09-30
标题 :A kind of efficient halogenation synthesis method of aryl halide

专利号:US-11286268-B1
优先权日:2019-07-02
标题:EIF4E-inhibiting compounds and methods
发明人：SPERRY SAMUEL; XIANG ALAN X; ERNST JUSTIN T; REICH SIEGFRIED H; SPRENGELER PAUL A; SHAGHAFI MIKE; MICHELS THEO; NILEWSKI CHRISTIAN; TRAN CHINH VIET; PACKARD Garrick Kenneth; GRUBBS ALAN; URKALAN KAVERI; MUKAIYAMA TAKASUKE
权利人:EFFECTOR THERAPEUTICS INC
摘要:The present invention provides synthesis, pharmaceutically acceptable formulations and uses of compounds in accordance with Formula I, or a stereoisomer, tautomer or pharmaceutically acceptable salt thereof. n n n n n n n n n n For Formula I compounds X 1 , X 2 , X 3 , X 4 , X 5 , X 6 , Q, L 1 , L 2 , Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and rings A, B and C are as defined in the specification. The inventive Formula I compounds are inhibitors of eIF4e and find utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.

专利号:CN-112573978-B
优先权日:2019-09-30
标题 :A kind of efficient halogenation synthesis method of aryl halide