CAS: 54-20-6; 5-(Trifluoromethyl)Pyrimidine-2,4(1H,3H)-Dione

相似化合物

65-71-4 65-71-4 4425-56-3

上下游产品

CAS号2314-97-8 三氟碘甲烷 | CAS号66-22-8 尿嘧啶 | CAS号2926-29-6 三氟代甲烷亚磺酸钠 | CAS号2145-56-4 5,6-二氢-5-三氟甲基尿嘧啶 | CAS号116393-64-7 1,3-bis(benzylo... | CAS号371-76-6 Bis[trifluorome... | CAS号7057-43-4 5-三氟甲基-2,4-双三甲基硅氧基嘧啶 | CAS号57-13-6 尿素 | CAS号105480-41-9 5-hydroxy-5-(tr... | CAS号3932-97-6 2,4-二氯-5-三氟甲基嘧啶 | CAS号70-00-8 曲氟尿苷 | CAS号65-71-4 胸腺嘧啶 | CAS号66-22-8 尿嘧啶 | CAS号25509-03-9 1-(oxolan-2-yl)... | CAS号16317-75-2 3-prop-2-enyl-5... | CAS号7057-43-4 5-三氟甲基-2,4-双三甲基硅氧基嘧啶 | CAS号78097-09-3 1-(2-羟基乙氧基甲基)-5... | CAS号939791-38-5 PF 562271 苯磺酸盐

5,6-二氢-5-三氟甲基尿嘧啶置于copper(Ll) Bromide体系中,用 溶剂黄146,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 14.0H,以82%的收率获得产物5-三氟甲基尿嘧啶
参考文献:A Facile Conversion Of 5-Trifluoromethyl-5,6-Dihydrouracils To 5-Trifluoromethyluracils
标题:A Facile Conversion Of 5-Trifluoromethyl-5,6-Dihydrouracils To 5-Trifluoromethyluracils
摘要:在二甲基甲酰胺/水或二甲基甲酰胺/乙酸中,5-三氟甲基-5,6-二氢尿嘧啶与溴化铜(II)反应,直接转化为相应的 5-三氟甲基尿嘧啶,收率非常好至极佳.
DOI:10.1246/cl.1984.1595

专利信息

专利号:US-2015239796-A1
优先权日:2014-02-19
标题:One pot synthesis of 18f labeledtrifluoromethylated compounds with difluoro(iodo)methane
发明人：RüHL THOMAS; RISS PATRICK; RAFIQUE WAQAS
权利人:UNIV OSLO
摘要:The present invention relates to compositions and methods for the synthesis of 18 F labeled compounds. In particular, the present invention relates to a copper (I) mediated one pot method for 18 F-trifluoromethylation of aromatic- or heteroaromatic halides with difluoro(iodo)methane (e.g., for use at PET imaging agents).

专利号:US-2014135497-A1
优先权日:2012-11-13
标题 :Synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine
发明人：LIU LI; AKALAY DENIZ; DONG WEITONG; FENG JIANQING; HEMP CHRISTIAN WOLFGANG; LU JUN; XIE LE; YANG JINSONG
权利人:LIU LI; AKALAY DENIZ; DONG WEITONG; FENG JIANQING; HEMP CHRISTIAN WOLFGANG; LU JUN; XIE LE; YANG JINSONG; BOEHRINGER INGELHEIM INT
摘要:This invention relates to a novel method for the synthesis of 2,4-dichloro-5-trifluoromethyl-pyrimidine useful as intermediate in the manufacture of pharmaceutically active ingredients.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-6624294-B2
优先权日:1999-01-08
标 题:Regioselective synthesis of 2′-O-modified nucleosides
发明人：KAWASAKI ANDREW M; FRASER ALLISTER S; MANOHARAN MUTHIAH; COOK P DAN; PRAKASH THAZHA P
权利人:ISIS PHARMACEUTICALS INC
摘要:Methods for the regioselective alkylation at the 2'-hydroxy position over the 3'-hydroxy position of nucleosides and nucleoside analogs, forming 2'-O-ester modified compounds, are disclosed. Reduction and derivatization of the 2'-O-ester provides 2'-O-modified nucleosides and nucleoside analogs useful for the synthesis of oligomeric compounds having improved hybridization affinity and nuclease resistance.

专利号:US-4849513-A
优先权日:1983-12-20
标 题 :Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

专利号:US-5118802-A
优先权日:1983-12-20
标 题:DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
发明人：SMITH LLOYD M; FUNG STEVEN; KAISER JR ROBERT J
权利人:CALIFORNIA INST OF TECHN
摘要:The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.