CAS: 41787-69-3; (βs,1S,4Ar,5S,8Ar)-5-Carboxy-Decahydro-β,5,8A-Trimethyl-2-Methylenenaphthalene-1-Pentanoic Acid

📜Imbricataloic Acid置于potassium Permanganate体系中,用 水,丙酮 作为反应溶剂,化学反应 2.0H,以4 Mg的收率获得产物南亚松酸
参考文献:In Vitro Biotransformations Of Isocupressic Acid By Cow Rumen Preparations: Formation Of Agathic And Dihydroagathic Acids
标题:In Vitro Biotransformations Of Isocupressic Acid By Cow Rumen Preparations: Formation Of Agathic And Dihydroagathic Acids
摘要:Isocupressic Acid [15-Hydroxylabda-8(17),13E-Dien-19-Oic Acid] (I) Was Incubated Under Anaerobic Conditions For 48 H In An In Vitro Luminal Fluid Mixture And Was Transformed Into Two Metabolites. The Two Metabolites Were Identified By Gc/ms As Agathic Acid [labda-8(17),13(E)-Diene-15,19-Dioic Acid] (4E) And Dihydroagathic Acid [labda-8(17)-Ene-15,19-Dioic Acid] (6). Metabolite Identities Were Confirmed By Chemical Conversions Of Isocupressic Acid (1) And Imbricataloic Acid (5) Into 4E And 6,Respectively. Structures Of Synthetic Metabolites Were Confirmed By H-1 And C-13 NMR,Specific Rotation,Gc/ms,And High-Resolution Mass Spectrometry. Plasma Obtained From Cows That Were Fed Ponderosa Pine Needles Contained (13R,S)-Dihydroagathic Acid (6) But Not Isocupressic Acid (1) Or 4E. The Results Suggest That Isocupressic Acid (1) Is Metabolically Oxidized To Agathic Acid (4E),Subsequently Reduced To (13R,S)-Dihydroagathic Acid (6) In The Rumen,And Then Absorbed Into The Bloodstream Of Cattle.
DOI:10.1021/np970372U