CAS: 41513-04-6; 1-Bromo-4-Chloro-2-Nitrobenzene

上下游产品

CAS号89-63-4 邻硝基对氯苯胺 | CAS号106-39-8 对氯溴苯 | CAS号539-03-7 N-(4-氯苯基)乙酰胺 | CAS号7697-37-2 硝酸 | CAS号50892-62-1 8-氯-5,10-二氢-11H... | CAS号91-39-4 4-氯-2-硝基二苯醚 | CAS号17422-33-2 6-氯吲哚 | CAS号29608-78-4 1,1'-Biphenyl,4... | CAS号292636-12-5 4-氯-1H-吲哚-7-胺 | CAS号823-57-4 2-溴-5-氯苯胺 | CAS号89-21-4 4-氯-2-硝基苯甲醚 | CAS号67990-66-3 N-(2-氨基-4-氯苯基)邻氨基苯甲酸 | CAS号126811-29-8 7-溴-4-氯-1H-吲哚 | CAS号13659-23-9 2-溴-5-氯苯酚

1-(4-氯-2-硝基苯)乙酮置于sodium Tetrahydroborate,1,10-菲罗啉,氧气,Potassium Carbonate体系中,用 甲醇,二甲基亚砜 作为反应溶剂,140.0 °C,500.01 Kpa 条件下,反应 36.0H,反应生成 2-溴-5-氯硝基苯
参考文献:芳基醇的c(芳基)-C键的脱羟基烷基卤化.
标题:芳基醇的c(芳基)-C键的脱羟基烷基卤化.
摘要:我们在本文中报道了铜介导的芳醇的侧向脱羟基烷基化卤化.有效裂解芳基醇的c(芳基)-c键,以优异的收率提供相应的芳基氯化物,溴化物和碘化物.在反应过程中,芳醇既可以用作芳族亲电子基团,也可以用作自由基合成基团.
DOI:10.1039/d0Cc02306J

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-2012172350-A1
优先权日:2009-09-11
标题 :Histamine h3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, including, e.g., neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as, e.g., histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical compositions containing the compounds and their methods of use are also provided herein.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:WO-2009000413-A1
优先权日:2007-06-26
标题:A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:US-8404670-B2
优先权日:2009-02-11
标题:Histamine H3 inverse agonists and antagonists and methods of use thereof
发明人：CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L
权利人:CHYTIL MILAN; ENGEL SHARON R; FANG QUN KEVIN; SPEAR KERRY L; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are fused imidazolyl compounds, methods of synthesis, and methods of use thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders and metabolic disorders. Compounds provided herein inhibit the activity of histamine H3 receptors and modulate the release of various neurotransmitters, such as histamine, acetylcholine, norepinephrine, and dopamine (e.g. at the synapse). Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

专利号:AU-2008267444-A1
优先权日:2007-06-26
标 题 :A regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles