专利号:US-7598291-B2 优先权日:2004-09-02 标题 :Methods and compositions for enhancing collagen and proteoglycan synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid, a lipoic acid analogue or derivative, a bioflavonoid, a constituent of ginkgo, or an isoflavone. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-2010160244-A1 优先权日:2004-09-02 标 题 :Methods and compositions for enhancing collagen, proteoglycan, and glutathione synthesis in the skin 发明人:NIMNI MARCEL; HAN BO 权利人:NIMNI MARCEL; HAN BO 摘要:A composition for application to the skin can stimulate the in vivo synthesis of collagen and proteoglycans and improve the appearance of the skin, increasing its elasticity and fullness. In general, a composition according to the present invention comprises: (1) an antioxidant compound in a quantity sufficient to enhance collagen synthesis in the skin; (2) an organic penetrant in which the antioxidant compound is soluble in a sufficient quantity that a concentration of the antioxidant compound sufficient to enhance collagen synthesis can be applied topically and penetrate the skin; (3) a mixture of essential amino acids or hydrolyzed whey protein; (4) a supplemental source of sulfur; and (5) a topical pharmaceutically acceptable carrier. The antioxidant compound can be lipoic acid or a lipoic acid analogue or derivative. The organic penetrant is preferably benzyl alcohol. Other ingredients, such as esters of tocopherol and ascorbic acid, can be included.
专利号:US-6849701-B2 优先权日:2001-03-02 标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers 发明人:NORTON TUCKER 权利人:DU PONT 摘要:A droplet polymerization process is provided to create efficacious molecularly imprinted polymers (MIPs). Such imprinted polymers have increased surface area for adsorptive or catalytic reactions. This method provides for monomer-template interactions in the absence of a suspending medium, thereby permitting formation of MIPs with increased template selectivity and substantial processing advantages. The process is particularly useful for separating isoflavones from soy whey.
专利号:US-7202398-B2 优先权日:2002-08-16 标 题 :Chalcone isomerase 发明人:MCGONIGLE BRIAN 权利人:DU PONT 摘要:An isolated nucleic acid fragment encoding a chalcone isomerase is disclosed. Also of concern is the synthesis of a recombinant DNA construct encoding all or a portion of the chalcone isomerase, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels of the chalcone isomerase in a transformed host cell.
专利号:US-2002198349-A1 优先权日:2001-03-02 标 题:Droplet polymerization method for synthesis of molecularly imprinted polymers
专利号:CN-104761627-A 优先权日:2015-04-20 标 题:Application of GmbHLH Transcription Factor in Promoting the Synthesis of Soybean Isoflavones
1: Kim YM, Huh JS, Lim Y, Cho M. Soy Isoflavone Glycitin (4'-Hydroxy-6-Methoxyisoflavone-7-D-Glucoside) Promotes Human Dermal Fibroblast Cell Proliferation and Migration via TGF-β Signaling. Phytother Res. 2015 May;29(5):757-69. doi: 10.1002/ptr.5313. Epub 2015 Mar 11. doi: 10.1080/09168451.2014.955453. Epub 2014 Sep 11. Epub 2016 Sep 13. 5: Li XH, Zhang JC, Sui SF, Yang MS. Effect of daidzin, genistin, and glycitin on osteogenic and adipogenic differentiation of bone marrow stromal cells and adipocytic transdifferentiation of osteoblasts. Acta Pharmacol Sin. 2005 Sep;26(9):1081-6. doi: 10.1021/jf204432g. Epub 2012 Feb 1. doi: 10.1093/chromsci/bmu045. Epub 2014 May 28. doi: 10.3109/09637486.2016.1144724. Epub 2016 Feb 16. doi: 10.1038/emm.2016.167. 11: van der Velpen V, Geelen A, Hollman PC, Schouten EG, van 't Veer P, Afman LA. Isoflavone supplement composition and equol producer status affect gene expression in adipose tissue: a double-blind, randomized, placebo-controlled crossover trial in postmenopausal women. Am J Clin Nutr. 2014 Nov;100(5):1269-77. doi: 10.3945/ajcn.114.088484. Epub 2014 Aug 20. doi: 10.3109/09637486.2015.1095861. Epub 2015 Oct 12. doi: 10.1111/1750-3841.13236. Epub 2016 Jan 27. doi: 10.3797/scipharm.1410-02. Print 2015 Apr-Jun.
合成参考文献
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