CAS: 39634-42-9; 4-(4-(Trifluoromethyl)Phenoxy)Phenol

上下游产品

4-methoxyphenoxy-4-trifluoromethylphenyl ether 4-(4-Trifluoromethylphenoxy)benzaldehyde 4-Fluorobenzotrifluoride hydroquinone 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-pentanoic acid 3-Methyl-2-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-butyric acid 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-butyric acid 2-[4-(4-Trifluoromethyl-phenoxy)-phenoxy]-hexanoic acid

📜对三氟甲基苯酚置于potassium Carbonate,间氯过氧苯甲酸体系中,用 N,N-二甲基乙酰胺 作为反应溶剂,化学反应生成 4-[(4-三氟甲基)苯氧基]苯酚
参考文献:5-芳基噻唑烷-2,4-二酮类作为选择性pparγ激动剂.
标题:5-芳基噻唑烷-2,4-二酮类作为选择性pparγ激动剂.
摘要:设计,合成了一系列含有4-苯氧基苯基侧链的5-芳基噻唑烷-2,4-二酮,并评估了其ppar激动剂的活性.一种这样的化合物28在db / Db小鼠2型糖尿病动物模型中显示出与罗格列酮相当的葡萄糖校正水平.
DOI:10.1016/s0960-894X(03)00257-9

专利信息

专利号:EP-0058173-B1
优先权日:1980-08-26
标 题:Process for the synthesis of aryloxy derivatives
摘要:Process for the synthesis of compounds of formula I (FORMULA) wherein O, is a substituted or unsubstituted aryl or heteroaryl group and U and V may be chosen from a range of substituents including hydrogen, halogen, alkyl and alkoxy; the process comprising reacting a sulfate ester of formula II, wherein Q is a cation, with a compound of formula III, wherein L is a leaving group (FORMULA) and hydrolysing the sulfate ester formed. Preferably the sulfate ester of formula II is prepared by the oxidation of a phenol of formula IV with a persulfate.

专利号:US-4450308-A
优先权日:1980-02-08
标 题:Process for the preparation of trifluoromethylphenyl oxyphenyl ether compounds
发明人：FOERSTER HEINZ; PRIESNITZ UWE
权利人:BAYER AG
摘要:New process for the preparation of known trifluoromethylphenyl oxyphenyl ether compounds of the formula ##STR1## wherein X stands for fluorine, chlorine or bromine and n R for moieties, substituted if desired, of the series alkyl, alkenyl and alkinyl, n by reacting 1,2-dihalogen-4-trifluoromethylbenzenes of the formula ##STR2## in which X and X 1 independently of one another stand for fluorine, chlorine or bromine, n with phenols of the formula ##STR3## in which R has the meaning given above, and basic alkali or alkaline earth compounds or with the salts formed from the phenols of formula (III) and the basic alkali or alkaline earth compounds, in the presence of diluents at temperatures between 60° and 120° C. n The compounds of the formula (I) are intermediates for the synthesis of herbicides.

专利号:US-2010120784-A1
优先权日:2007-04-20
标题 :Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
权利人:LACHANCE NICOLAS; LI CHUN SING; LECLERC JEAN-PHILPPE; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula (I) or a pharmaceutically acceptable salt thereof, wherein W is a substituted heteroaryl, X and Y are each independently a bond, —O—, —S—, —S(O)—, —S(O) 2 —, —NR 6 —, —C(O)—, —C(CH 3 )(OH)— or —C(CH 3 )â•?CH—, u (I) is an integer from 1 to 4, and Ar is an optionally substituted phenyl or naphtyl, are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD) The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis, obesity, Type 2 diabetes, insulin resistance, hyperglycemia, Metabolic Syndrome, neurological disease, cancer, and liver steatosis

专利号:EP-0052836-A1
优先权日:1980-11-22
标 题 :Phenoxybenzaldehydes and process for their preparation
发明人：HUETTELMAIER THOMAS DR; MILDENBERGER HILMAR DR; MATTERSTOCK KARL DR
权利人:HOECHST AG
摘要:Phenoxybenzaldehydes of the formula in which R1 is halogen, CN, NO2, (cyclo) alkyl, alkoxy, alkylthio, haloalkyl or methylenedioxy; R2 radicals of the formulas R3 H, halogen, CN, NO2, (halogen) alkyl, alkoxy, alkylthio; R2 + R3 also an (un) saturated hydrocarbon chain; X -O-, -S-, -SO-, -SO2-, -OCH2-, -CH2O-, -CH2-, -SCH2-, -CH2S-, -CO-, -CH = CH-, -N- or a chemical bond; Y O or S; R4 is halogen, CN, NO2, (halogen) alkyl, (halogen) alkoxy, cycloalkyl, alkoxy, alkylthio, phenyl or methylenedioxy, R5 is H, alkyl or cycloalkyl, n 0-5 and m 0-4 are starting materials for the Synthesis of effective insecticides and acaricides.

专利号:EP-0100425-A1
优先权日:1982-07-03
标题:Substituted diphenyl ethers, process for their preparation and their use as herbicides
发明人：FUEHRER WOLFGANG DR; STETTER JOERG DR; EUE LUDWIG DR; SCHMIDT ROBERT R DR
权利人:BAYER AG
摘要:R 1 für Halogen oder Trifluormethyl steht, R 2 für Wasserstoff, Halogen, Trifluormethyl oder Nitro steht, R 3 für Wasserstoff oder Halogen steht, R 4 für Wasserstoff, Halogen oder Nitro steht, R 5 für Wasserstoff oder Alkyl mit 1 bis 5 Kohlenstoffatomen steht, R 6 für Alkyl, Alkenyl, Alkinyl oder Alkoxyalkyl steht und X für Sauerstoff oder Schwefel steht, mehrere Verfahren zur Herstellung der erfindungsgemäßen Stoffe und deren Verwendung als Herbizide. Neue Ausgangsstoffe zut Herstellung der erfindungsgemäßen Verbindungen und die Synthese dieser neuen Ausgangsstoffe. New substituted diphenyl ethers of the formula in which R 1 represents halogen or trifluoromethyl, R 2 represents hydrogen, halogen, trifluoromethyl or nitro, R 3 represents hydrogen or halogen, R 4 represents hydrogen, halogen or nitro, R 5 represents hydrogen or alkyl having 1 to 5 carbon atoms, R 6 represents alkyl, alkenyl, alkynyl or alkoxyalkyl and X represents oxygen or sulfur, several processes for the preparation of the substances according to the invention and their use as herbicides. New starting materials for the preparation of the compounds according to the invention and the synthesis of these new starting materials.

专利号:WO-8200638-A1
优先权日:1980-08-26
标 题 :Process for the synthesis of aryloxy derivatives