CAS: 30925-07-6; (2R,2'R)-3,3'-Disulfanediylbis(2-Aminopropanoic Acid) Dihydrochloride

相似化合物

56-89-3 10389-65-8 34760-60-6

📜L-半胱氨酸置于盐酸,过氧化氢异丙苯,Tert-Butyl (S)-(Tetrahydrotellurophen-3-yl)Carbamate体系中,用 二氯甲烷,水 作为反应溶剂,以100%的收率获得产物l-胱氨酸盐酸盐
参考文献:具有出色的类似谷胱甘肽过氧化物酶活性的环状碲化物试剂,无需纯化即可合成高纯度的有机二硫化物†
标题:具有出色的类似谷胱甘肽过氧化物酶活性的环状碲化物试剂,无需纯化即可合成高纯度的有机二硫化物†
摘要:具有五元或六元环结构的单氨基环状碲化物及其衍生物被开发为一类新的催化剂,用于在谷胱甘肽过氧化物酶样催化反应中将有机硫醇氧化为有机二硫化物.通过在有机-水分段微流系统中进行反应,可以实现定量转化和高反应速率.重要的是,该方法避免了产物纯化,这是当前有机二硫化物合成方法的主要限制.
DOI:10.1039/c9Cy00562E

专利信息

专利号:US-12391691-B2
优先权日:2018-11-16
标题:Synthesis of key intermediate of KRAS G12C inhibitor compound
发明人：PARSONS ANDREW THOMAS; COCHRAN BRIAN MCNEIL; POWAZINIK IV WILLIAM; CAPORINI MARC ANTHONY
权利人:AMGEN INC
摘要:The present invention relates to an improved, efficient, scalable process to prepare intermediate compounds, such as compound 5M, having the structure n nuseful for the synthesis of compounds that target KRAS G12C mutations, such as

专利号:US-2025206736-A1
优先权日:2019-11-14
标题 :Synthesis of kras g12c inhibitor compound
发明人：CORBETT MICHAEL THOMAS; CAILLE SEBASTIEN
权利人:AMGEN INC
摘要:The present disclosure relates to an improved, efficient, scalable process to prepare intermediate compounds, such as 2-isopropyl-4-methylpyridin-3-amine, useful for the synthesis of compounds, such as Compound 9, for the treatment of KRAS G12C mutated cancers.

专利号:US-2023266302-A1
优先权日:2020-07-24
标 题:Synthesis and use of n-benzyl sulfonamides
发明人：LAMAR ANGUS A; SHEAFF ROBERT J
权利人:THE UNIV OF TULSA
摘要:Disclosed is a method for preparing N-benzyl sulfonamides. Also disclosed is a composition for treating cancer. The composition includes a N-benzyl sulfonamide and a metabolic inhibitor. Also disclosed is a method for determining the impact on cell ATP levels of a composition containing a N-benzyl sulfonamide with or without a metabolic inhibitor.

专利号:US-2006223147-A1
优先权日:2004-08-05
标题 :Process for producing glycoprotein composition
发明人：NISHIYA HARUE; SATOH MITSUO; MORI KATSUHIRO
权利人:KYOWA HAKKO KOGYO KK
摘要:The present invention relates to a cell into which an RNA capable of suppressing the function of an enzyme catalyzing a reaction which converts GDP-mannose into GDP-4-keto,6-deoxy-GDP-mannose is introduced; a process for producing a glycoprotein using the cell; a cell into which an RNA capable of suppressing the function of an enzyme relating to modification of a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in the complex type N-glycoside-linked sugar chain, and an RNA capable of suppressing the function of an enzyme relating to synthesis of an intracellular sugar nucleotide, GDP-fucose, or an RNA capable of suppressing the function of a protein relating to transport of an intracellular sugar nucleotide, GDP-fucose, to the Golgi body are introduced; a process for producing a glycoprotein composition using the cell; and the like.

专利号:US-2023192682-A1
优先权日:2019-11-14
标题:Improved synthesis of kras g12c inhibitor compound

专利号:US-2023192681-A1
优先权日:2019-11-14
标 题 :Improved synthesis of kras g12c inhibitor compound