CAS: 28188-41-2; 3-(Bromomethyl)Benzonitrile

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CAS号874-97-5 3-羟甲基苯甲腈 | CAS号10406-24-3 3-氨甲基-苯甲腈 | CAS号620-22-4 间甲基苯腈 | CAS号64407-07-4 间氰基氯苄 | CAS号7726-95-6 溴素 | CAS号104508-27-2 3-(苯氧基甲基)苯甲醛 | CAS号34136-57-7 3-乙基苯腈 | CAS号620-22-4 间甲基苯腈 | CAS号31719-75-2 3-(苯氧基甲基)苯甲酸 | CAS号148278-90-4 (3-(甲氧基甲基)苯基)甲胺 | CAS号928708-60-5 1-(吡啶-3-甲基)-1H-... | CAS号93717-55-6 2-氰基-4’-甲基联苯 | CAS号90389-96-1 N-甲基-3-氰基苄胺 | CAS号2084-13-1 3-(羧基甲基)苯甲酸 | CAS号193152-99-7 Methyl (2R,3R)-...

间甲基苯腈置于n-溴代丁二酰亚胺(Nbs),过氧化氢苯甲酰体系中,用 四氯化碳 用作溶剂,化学反应生成3-氰基苄基溴
参考文献:羧酸盐桥接的钴(III)的四氮杂大环配合物的结构
标题:羧酸盐桥接的钴(III)的四氮杂大环配合物的结构
摘要:合成了具有精心选择的侧基的新的大环配体,并制备了其钴(III)配合物并通过x射线晶体学表征.1,4,7,10-四-Azacyclododecane-ñ-米制备-Toluic酸通过相应的腈,从米-Cyanobenzyl-溴化物和四azamacrocycle,随后形成的钴(III)络合物,然后水解络合物中的氰基.该结构揭示了一种新颖的双核结构,其中像两个金属离子一样悬挂着羧基.这与分子设计是一致的,因为选择了侧基以防止羧基螯合到与母体大环相同的金属离子上.晶体数据:[{co(c 16 H 25 N 4 O 2)h 2 O} 2 ] [clo 4 ] 4 .6H 2 O:正交晶,空间群pbcn,A = 25.346(7),B = 15.722(2) ),C = 25.720(4)å,Z = 8(二聚体)和[r = 0.064 2 806独特观测到的[我/σ(我)3.0]反射.该晶体包含两
Doi:10.1039/dt9900000257

专利信息

专利号:WO-9943409-A1
优先权日:1998-02-27
标 题:Hplc fractionation of complex chemical mixtures
发明人：COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
权利人:ISIS PHARMACEUTICALS INC; COOK PHILLIP DAN; CUMMINS LENDELL L; GRIFFEY RICHARD H; KAWASAKI ANDREW M; GAUS HANS; AN HAOYUN
摘要:The rapid deconvolution of complex chemical mixtures, such as combinatorial libraries prepared via solution-phase simultaneous addition of functionalities is demonstrated using HPLC. Libraries containing 25-216 members were screened for biological activity and active libraries are fractionated into discreet pools using preferred reversed-phase HPLC. The entire process can be completed from a single synthesis of 15-50 mg, without the need for fixed positions, serial synthesis, or tagging.

专利号:US-6150129-A
优先权日:1996-08-01
标 题 :Antimicrobial determination of N-(aminoalkyl) and/or N-(Amidoalkyl) dinitrogen heterocyclic compositions
发明人：COOK PHILLIP DAN; KAWASAKI ANDREW M; KUNG PEI PEI
权利人:ISIS PHARMACEUTICALS INC
摘要:Compositions are provided comprising novel di-nitrogen heterocycle compounds containing N-(aminoalkyl) and/or N-(amidoalkyl) groups. An additional situs of functionality is also provided. The compounds and compositions of the invention are useful as antibacterial and other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents including employment as species for effecting combinatorial synthesis.

专利号:EP-1836163-B1
优先权日:2004-12-23
标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
发明人：BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
权利人:NOVARTIS AG
摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

专利号:FR-2685323-A1
优先权日:1991-12-19
标 题 :MERCAPTOMETHYLBENZYLAMINES AND THEIR USE IN THE SYNTHESIS OF BISPHENOLS.

专利号:US-12410142-B2
优先权日:2017-04-07
标 题:Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof
发明人：DENG XIANMING; LIN SHENGCAI; ZHANG CHENSONG
权利人:XIAMEN VIVOHEALTHS TECH CO LTD
摘要:Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:

专利号:US-7518905-B2
优先权日:1999-07-01
标 题 :High density memory device
发明人：BOCIAN DAVID F; KUHR WERNER G; LINDSEY JONATHAN; CLAUSEN PETER CHRISTIAN; GRYKO DANIEL TOMASZ
权利人:UNIV CALIFORNIA; UNIV NORTH CAROLINA STATE
摘要:This invention provides novel high density memory devices that are electrically addressable permitting effective reading and writing, that provide a high memory density (e.g., 10 15 bits/cm 3 ), that provide a high degree of fault tolerance, and that are amenable to efficient chemical synthesis and chip fabrication. The devices are intrinsically latchable, defect tolerant, and support destructive or non-destructive read cycles. In a preferred embodiment, the device comprises a fixed electrode electrically coupled to a storage medium having a multiplicity of different and distinguishable oxidation states wherein data is stored in said oxidation states by the addition or withdrawal of one or more electrons from said storage medium via the electrically coupled electrode.