CAS: 185847-84-1; Benzyl 4-Oxo-3,4-Dihydropyridine-1(2H)-Carboxylate

该化合物是一种化学化合物,其特点是其独特的结构,包括二羟丙烯环和碳bylate功能组;该化合物通常由于存在苯基组和类似丙烯基的结构,而具有芳香和丙烯基和丙烯基系统特性;在室内温度下可能很固,有机溶剂中具有中等溶解性,反映其功能组对极性的影响;该化合物可参与各种化学反应,包括核细胞替代和循环添加剂,因为碳基和二羟丙烯酸混合物具有再活动性;此外,该化合物还可能展示生物活动,引起对医药化学的兴趣;其化学文摘号为185847-84-1,便于在化学数据库中识别,便利在各个领域的研究和应用,包括制药和有机合成.

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合成工艺路线路线简述

    📜Benzyl 6-Bromo-1,4-Dioxa-8-Azaspiro[4.5]Decane-8-Carboxylate置于1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 二甲基亚砜 用作溶剂,化学反应生成4-氧代-3,4-二氢吡啶-1(2H)-羧酸苄酯
    参考文献: 5-(Arylsulfonyl)-Pyrazolopiperidines[fr] 5-(Arylsulfonyl)-Pyrazolopiperidines
    标题: 5-(Arylsulfonyl)-Pyrazolopiperidines[fr] 5-(Arylsulfonyl)-Pyrazolopiperidines

    海关参考信息

    专利信息


    专利号:US-2025270185-A1
    优先权日:2024-02-28
    标题 :Method for preparation of iptacopan hydrochloride
    发明人：ZHANG YIPING; LIU QIAOLING; WU YIHUA; ZHENG XUCHUN
    权利人:HANGZHOU CHEMINSPIRE TECH CO LTD
    摘要:A synthesis method for iptacopan is provided, which includes the asymmetric addition of compound 1 as the starting material with compound 2 benzyl 4-oxo-3,4-dihydropyridine-1(2H)-carboxylate under the action of a metal catalyst and ligand to obtain intermediate compound 3; then, carbonyl group being enzymatically reduced to obtain compound 4; compound 4 undergoing catalytic conversion from the cyano group to the carboxyl group under the action of a cyano hydrolysis enzyme in a one-pot reaction; subsequently, hydroxy groups completing the ethylation reaction; after palladium hydrogenation, key intermediate compound 6 of iptacopan being obtained; finally, compounds 6 and 7 undergoing reduction amination condensation, followed by removing the Boc group to form the target product: hydrochloride salt of iptacopan. This method features a simple process route, high yield, and low costs, which is suitable for industrial production.

    专利号:CN-118126021-A
    优先权日:2024-02-28
    标 题 :A kind of synthesis method of ipracopan hydrochloride

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    合成参考文献


    摘要:Nubbemeyer, U., Science of Synthesis, (2008) 32, 245.
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