CAS: 180675-08-5; (S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-4-((3-Methylpentan-3-yl)Oxy)-4-Oxobutanoic Acid
该化合物是一种常见于peptide合成和有机化学的化学化合物,其特点是氟酰甲基碳酸乙烯(FMOC),该组是氨基功能的保护组,可以不受矿物质干扰地进行选择性反应;无成分酸成分有助于其在peptide合成中发挥作用,提供一个可参与组合反应的箱式酸组;OMPE组增强化合物的稳定性和溶性,使之适合各种合成应用;FMOC-ASP(OMPE)-OHA,该组通常用于固相聚聚,其中功能组的保护和减少保护对聚苯乙烯的成功组合至关重要;其特性包括有机溶解性良好,在标准实验室条件下稳定,以及与各种组合试剂兼容性反应.
- 英文名称(S)-2-((((9H-Fluoren-9-yl)Methoxy)Carbonyl)Amino)-4-((3-Methylpentan-3-yl)Oxy)-4-Oxobutanoic Acid
- 中文名称(S)-2-(((9H-芴-9-基)甲氧基)羰基)氨基)-4-((3-甲基戊-3-基)氧基)-4-氧代丁酸
- IUPAC名称(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-((3-methylpentan-3-yl)oxy)-4-oxobutanoic acid
- 其它别名N-[芴甲氧羰基]-L-天冬氨酸 4-(1-乙基-1-甲基丙基)酯; Fmoc-Asp(Ompe)-Oh
- CAS编号180675-08-5
- MFCD编号:MFCD10001333
- EINECS号:858-825-4
- 分子式:C25H29NO6分子量:439.5
- 产品CID: 931460
- 产品分类有机原料→分子砌块→手性化合物→手性砌块
相似化合物
1926162-97-1 1799418-06-6 112883-39-3物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
3-methylpentan-3-ol N-(9-fluorenylmethoxycarbonyl)-L-aspartyl α-benzyl ester (S)-3-Chlor°Carbonyl-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid benzyl ester N-(9-fluorenylmethoxycarbonyl)-4-O-tert-butyl-D-aspartic acidL-3-aminosuccinimide human C-type natriuretic peptide 22合成工艺路线路线简述
📜Fmoc-L-天冬氨酸-1苄脂置于钯 草酰氯,氢气体系中,用 四氢呋喃 用作溶剂,化学反应 1.0H,反应生成N-[芴甲氧羰基]-L-天冬氨酸 4-(1-乙基-1-甲基丙基)酯
参考文献:一种新的天冬氨酸保护基团,可在fmoc固相肽合成中最大程度地减少哌啶催化的天冬氨酸形成
标题:一种新的天冬氨酸保护基团,可在fmoc固相肽合成中最大程度地减少哌啶催化的天冬氨酸形成
摘要:Fmoc天冬氨酸的β-3-甲基戊-3-基酯fmoc-Asp(ompe)-Oh作为天冬氨酸的新保护基团提供,它对fmoc固相肽中的碱催化天冬酰胺形成提供了非常好的保护合成.
Doi:10.1016/0040-4039(96)00807-6
海关参考信息
- 2902600000-乙苯
2905122000-异丙醇
2905143000-叔丁醇
2905399002-1,4-丁二醇 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:WO-2025078040-A1
优先权日:2023-10-09
标 题 :Lysine salt and method of manufacturing a lysine derivative
发明人：HINTERMANN TOBIAS; SCHWINDLING JOACHIM; RÃœEFLI PASCAL; SCHÖNLEBER RALPH O; WILLIG FELIX; MELZIG LAURIN; ERMERT PHILIPP; KÃœMIN MICHAEL; SCHWIZER NATASCHA; SCHNEIDER ANGELIKA; SCHMID LUCIUS
权利人:BACHEM HOLDING AG
摘要:The invention relates to a Bsmoc-protected lysine salt of formula (1 X ), e.g., a hydrochloric acid salt (n = 1, HY = hydrochloric acid). It further relates to a method of manufacturing Bsmoc-protected lysine derivatives, which employs the Bsmoc-protected lysine salt of formula (1 X ) and comprises the step of reacting the epsilon amino group of lysine with an 10 activated carboxylic acid derivative. Some of the obtainable Bsmoc-protected lysine derivatives with their side chain modification are useful as starting materials in solid phase peptide synthesis.
专利号:WO-2011151826-A2
优先权日:2010-06-01
标题:An expeditious synthesis of ubiquitinated peptide conjugates
专利号:EP-3728304-B1
优先权日:2017-12-21
标题 :Solid phase synthesis of acylated peptides
专利号:EP-2575849-A2
优先权日:2010-06-01
标 题:An expeditious synthesis of ubiquitinated peptide conjugates
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Preventing Aspartimide Formation In Fmoc Spps Of Asp-Gly Containing Peptides - Practical Aspects Of New Trialkylcarbinol Based Protecting Groups作者:Raymond Behrendt,Simon Huber,Peter White |发布日期:2016.2
摘要:Universal Solution To The Problem Of Aspartimide Formation In Fmoc Spps, We Investigated The Application Of Our New β‐trialkylmethyl Protected Aspartic Acid Building Blocks To The Synthesis Of Peptides Containing The Asp‐gly Motif. The Nα‐fmoc Aspartic Acid β‐tri‐(Ethyl/propyl/butyl)Methyl Esters Were Used In The Synthesis Of The Classic Model Peptide Scorpion Toxin Ii (Vkdgyi), And Their Effectiveness In Minimising
合成参考文献
合成方法参考DOI号:10.1021/jacs.7b02988
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