CAS: 152460-09-8; N-(2-Methyl-5-Nitrophenyl)-4-(Pyridin-3-yl)Pyrimidin-2-Amine

相似化合物

152460-10-1 152460-10-1 181065-58-7

上下游产品

CAS号404844-11-7 N-[4-甲基-3-(4-吡啶... | CAS号152459-95-5 伊马替尼

2-氨基-4-硝基甲苯置于硝酸,Sodium Hydroxide体系中,化学反应 12.0H,反应生成N-(2-甲基-5-硝基苯基)-4-(3-吡啶基)-2-嘧啶胺
参考文献:苯氨基氨基嘧啶和吲哚/羟吲哚共轭物作为潜在的bcr-Abl抑制剂的合成及生物学评估
标题:苯氨基氨基嘧啶和吲哚/羟吲哚共轭物作为潜在的bcr-Abl抑制剂的合成及生物学评估
摘要:摘要吲哚/靛红素共轭的苯基-氨基-嘧啶衍生物已经合成,表征并在体外评估了其作为bcr-Abl抑制剂的潜力.在该系列中,发现所有衍生物(7A-7O)对k-562细胞系的毒性都比标准伊马替尼更高.化合物7L是该系列中活性最高的化合物,效力比伊米替尼(ic 50)高出近两倍.0.65μm).重组abl激酶的体外酶学研究显示,对于这些新型结合物中的大多数,其抑制作用范围在30-71 µm之间.另外,已经进行了建模和其他计算研究以分别了解bcr-Abl蛋白与靶分子的相互作用以及缀合物的类药物性质. 苯氨基氨基嘧啶和吲哚/羟吲哚共轭物作为潜在的bcr-Abl抑制剂的合成和生物学评估.
Doi:10.1007/s00044-019-02318-4

专利信息

专利号:US-8334381-B2
优先权日:2006-11-16
标题 :Process for the preparation of intermediates useful in the synthesis of imatinib
发明人：FALCHI ALESSANDRO; GRENDELE ENNIO; MOTTERLE RICCARDO; STIVANELLO MARIANO
权利人:FALCHI ALESSANDRO; GRENDELE ENNIO; MOTTERLE RICCARDO; STIVANELLO MARIANO; ITALIANA SINT SPA
摘要:It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.

专利号:WO-2013035102-A1
优先权日:2011-09-05
标 题 :Processes for the preparation of imatinib base and intermediates thereof
发明人：KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
权利人:NATCO PHARMA LTD; KOMPELLA AMALA KISHAN; RACHAKONDA SREENIVAS; GAMPA VENU GOPALA KRISHNA; ADIBHATLA KALI SATYA BHUJANGA RAO; NANNAPANENI VENKAIAH CHOWDARY
摘要:The invention relates to an improved process for the preparation of highly pure imatinib base (99.99% HPLC purity) of formula (I) and the pharmaceutically acceptable acid addition salts thereof. This invention also relates to processes for the preparation of the intermediates in the synthesis of imatinib base.

专利号:WO-2023098592-A1
优先权日:2021-11-30
标题:Preparation method for carbon-loaded iron-based catalyst and use thereof in synthesis of intermediates of anti-cancer inhibitors

专利号:US-2023065387-A1
优先权日:2019-10-14
标题:Synthesis of tyrosine kinase inhibitors

专利号:US-2011097268-A1
优先权日:2006-08-23
标 题 :Radiohaloimatinibs and methods of their synthesis and use in pet imaging of cancers
发明人：BORNMANN WILLIAM; ALAUDDIN MIAN; GELOVANI JURI; GHOSH PRADIP; GUO LIWEI; HAN DONGMEI; MAXWELL DAVID; MUKHOPADHYAY UDAY; PENG ZHENGHONG; SHAVRIN ALEKSANDR; YING YUNMING
权利人:UNIV TEXAS
摘要:We disclose methods of synthesizing radiohalidated organic compounds and their use in positron emission tomography (PET) imaging of cancer cells.

专利号:WO-2021074138-A1
优先权日:2019-10-14
标题:Synthesis of 6-methyl-n1-(4-(pyridin-3-yl)pyrimidin-2-yl)benzene-1,3-diamine