CAS: 111493-74-4; Ethyl 1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate

相似化合物

113100-53-1 128225-66-1 141573-95-7

上下游产品

methylhydrazine ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate ethyl 5-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate N-methylsydnone(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)methanol 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 1-methyl-N-(4-methylpyridin-2-yl)-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide 1-methyl-3-trifluoromethyl-1H-pyrazole-4-carbonyl chloride

乙氧基-2-亚甲基三氟乙酰乙酸乙酯置于sodium Hydride,一水合肼体系中,用 甲醇,N,N-二甲基甲酰胺 用作溶剂,化学反应 23.33H,反应生成1-甲基-3-三氟甲基-1H-吡唑-4-羧酸乙酯
参考文献:Synthesis And Antifungal Activity Of N-(Substituted Pyridinyl)-1-Methyl(Phenyl)-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxamide Derivatives
标题:Synthesis And Antifungal Activity Of N-(Substituted Pyridinyl)-1-Methyl(Phenyl)-3-(Trifluoromethyl)-1H-Pyrazole-4-Carboxamide Derivatives
摘要:合成了一系列n-(取代吡啶基)-1-甲基(苯基)-3-三氟甲基-1H-吡唑-4-羧酰胺衍生物.所有目标化合物通过光谱数据(1H-NMR,13C-NMR,Ir,Ms)和元素分析进行了表征,并在体外对三种植物病原真菌(gibberella Zeae,Fusarium Oxysporum,Cytospora Mandshurica)进行了生物活性测试.结果表明,合成的一些n-(取代吡啶基)-1-甲基-3-三氟甲基-1H-吡唑-4-羧酰胺表现出中等的抗真菌活性,其中化合物6A,6B和6C在100 µg/ml时对g. Zeae的抑制活性超过50%,优于商业杀菌剂carboxin和boscalid.
Doi:10.3390/molecules171214205

专利信息

专利号:US-9676726-B2
优先权日:2013-12-23
标题:Process for the regioselective synthesis of pyrazoles
发明人：MEAZZA GIOVANNI; SILLANI LAURA; MEREGHETTI PIERANGELO; FORGIA DANIELE
权利人:ISAGRO SPA
摘要:A process is described for the synthesis of pyrazoles having general formula (I) n nwhich comprises the steps of mixing a compound having general formula (II)n n nand a 1,2-disubstituted hydrazine having general formula (III)n n nto form a reaction intermediate having general formula (IV)n n nand the reaction mixture obtained in step i), in an acid environment, cyclizes to form a pyrazole having general formula (I), according to reaction scheme 1

专利号:EP-3087058-A1
优先权日:2013-12-23
标 题:Process for the regioselective synthesis of pyrazoles

专利号:EP-3087058-B1
优先权日:2013-12-23
标 题:Process for the regioselective synthesis of pyrazoles

专利号:US-2016318874-A1
优先权日:2013-12-23
标 题:Process for the regioselective synthesis of pyrazoles

专利号:WO-2015097658-A1
优先权日:2013-12-23
标题 :Process for the regioselective synthesis of pyrazoles

专利号:DK-3087058-T3
优先权日:2013-12-23
标 题 :PROCEDURE FOR THE REGIOSELECTIVE SYNTHESIS OF PYRAZOLES