CAS: 1052114-81-4; 5-(4-Fluorophenyl)-4-Oxo-1,4-Dihydropyridine-3-Carboxylic Acid

英文名称5-(4-Fluorophenyl)-4-Oxo-1,4-Dihydropyridine-3-Carboxylic Acid
中文名称5-(4-氟苯基)-4-氧代-1,4-二氢吡啶-3-羧酸
IUPAC名称5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
其它别名5-(4-Fluorophenyl)-4-Oxo-1,4-Dihydropyridine-3-Carboxylic Acid; 3-Pyridinecarboxylic Acid, 5-(4-Fluorophenyl)-1,4-Dihydro-4-Oxo-; 5-(4-Fluorophenyl)-1,4-Dihydro-4-Oxo-3-Pyridinecarboxylic Acid; 5-(4-Fluorophenyl)-4-Oxo-1,4-Dihydropyridine-3-Carboxylic Ac
CAS编号1052114-81-4
MFCD编号:MFCD28965085
分子式:C12H8FNO3分子量:233.2
产品CID: 92542
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: IZTVDTIADHKZNM-UHFFFAOYSA-N
InChI=1S/C12H8FNO3/c13-8-3-1-7(2-4-8)9-5-14-6-10(11(9)15)12(16)17/h1-6H,(H,14,15)(H,16,17)
计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

相似化合物

80097-15-0 1261934-09-1 364064-17-5

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

上下游产品

ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate 4-Fluorophenylacetyl chloride 4-(4-fluorophenyl)-3-oxobutanoic acid ethyl ester methyl 5-bromo-4-oxo-1,4-dihydropyridine-3-carboxylate N-(4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide N-(4-(3-chloro-2-(diphenylmethyleneamino)pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide 5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1-aza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide 5-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-pyridine-3-carboxylic acid [3-fluoro-4-(7,8,10,11,13,14-hexahydro-6,9,12,15-tetraoxa-1,3-diaza-cyclododeca[b]naphthalen-4-yloxy)-phenyl]-amide

合成工艺路线路线简述

📜对氟苯乙酰氯置于n,N-二甲基甲酰胺二甲基缩醛,三乙胺,Sodium Hydroxide体系中,用甲醇,5,5-Dimethyl-1,3-Cyclohexadiene,二氯甲烷,水用作溶剂,化学反应 26.0H,反应生成5-(4-氟苯基)-4-氧代-1,4-二氢吡啶-3-羧酸
参考文献:4-(4-氨基苯氧基)吡啶-2-胺衍生物及其用途
标题:4-(4-氨基苯氧基)吡啶-2-胺衍生物及其用途
摘要:本发明提供了一种新的4‑(4‑氨基苯氧基)吡啶‑2‑胺衍生物,具有式i所示结构,其对ripk3具有优异的抑制效果,可作为ripk3的抑制剂,治疗细胞程序性坏死相关的疾病,具有重要的临床价值.