CAS: 944401-56-3; 5-Bromo-4-(Trifluoromethyl)Pyridin-2-Amine

化学文摘社编号944401-56-3允许在化学数据库中识别,促进包括药品和农用化学剂在内的各种应用的研究和开发.应参考安全数据,用于处理和储存,因为卤化化合物可能对环境和健康造成风险.

英文名称5-Bromo-4-(Trifluoromethyl)Pyridin-2-Amine
中文名称5-溴-4-(三氟甲基)吡啶-2-胺
IUPAC名称5-bromo-4-(trifluoromethyl)pyridin-2-amine
其它别名2-氨基-5-溴-4-(三氟甲基)吡啶; 2-Amino-5-Bromo-4-(Trifluoromethyl)Pyridine
CAS编号944401-56-3
MFCD编号:MFCD09864896
EINECS号:693-695-0
分子式:C6H4BrF3N2
分子量:241.01
产品CID: 1994912
产品分类有机原料→分子砌块→芳杂环类化合物→吡啶类化合物

相似结构搜索
InChIKey: AEWYLVDLWQPJGW-UHFFFAOYSA-N
InChI=1S/C6H4BrF3N2/c7-4-2-12-5(11)1-3(4)6(8,9)10/h1-2H,(H2,11,12)…
计算化学: 氢键受体数2.0氢键供体数1.0可旋转键数0.0

相似化合物

1805958-75-1 1208081-51-9 1542268-23-4

MSDS等安全信息

GHS象形图
GHS符号GHS07;
注释: Exclamation mark
危险类别急性毒性类别4(经口)
严重眼刺激类别2
急性毒性类别4(吸入)
急性毒性类别4(经皮)
特定目标器官毒性 - 单次接触类别3
皮肤腐蚀/刺激类别2
严重眼刺激类别2A
急性毒性类别3(经口)
皮肤致敏类别1
警示词Warning(警告)
危险描述H302 |吞咽有害.
H319 |造成严重眼刺激.
H332 |吸入有害.
H312 |皮肤接触有害.
H335 |可能引起呼吸道刺激.
H315 |造成皮肤刺激.
H301 |吞咽会中毒.
H317 |可能引起皮肤过敏反应.
防范说明P264-P270-P280-P330-P501
危险等级IRRITANT
UN编号NONH for all modes of transport
危险品标志Xn
安全声明22-24/25-26-36/37/39
危险类别码20/21/22-36/37/38-36-22
WGK Germany1

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号106447-97-6 2-氨基-4-(三氟甲基)吡啶 | CAS号944401-57-4 2-氨基-4-三氟甲基-5-吡... | CAS号106447-97-6 2-氨基-4-(三氟甲基)吡啶 | CAS号1312445-63-8 BKM120(盐酸盐)

合成工艺路线路线简述

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dimethylformamide; 5 °C -> Rt1.2 Reagents: Water
标题:Preparation Of Oxadiazolopyridine Derivatives For Use As Ghrelin O-Acyl Transferase (Goat) Inhibitors
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; 2 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Rt
标题:Mechanistic Target Of Rapamycin Signaling Pathway Inhibitors,Therapeutic Applications,And Preparation
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Tetrahydrofuran; 0 °C; 0 °C -> Rt; 1 H,Rt1.2 Reagents: Sodium Thiosulfate Solvents: Water; Rt
标题:Pyrimidine-Morpholine-Fused-Ring Compounds As Pi3K Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Proliferative Diseases
参考文献:China]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 2 H,Rt1.2 Reagents: Sodium Hydroxide Solvents: Dichloromethane,Water
标题:Preparation Of Imidazo[1,2-A]Pyridines And Imidazo[1,2-B]Pyridazines As Pi-3 Kinase Inhibitors
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 2 H,Rt
标题:Pyrimidine Derivatives Used As Pi-3 Kinase Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Cancer
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Tetrahydrofuran; 2 H,0 °C; 30 Min,3 °C -> 20 °C1.2 Reagents: Sodium Thiosulfate Pentahydrate Solvents: Water; 10 Min,20 °C; 1 H,20 °C
标题:Manufacturing Process For Pyrimidine Derivatives
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; 2 H,Rt
标题:Pyrazolyl Pyrrolinones And Their Use As Herbicides
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 0 °C; 2 H,25 °C
标题:Preparation Of Triazine Compounds As Antitumor Agent
参考文献:China]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; Overnight,Rt
标题:Preparation Of Pyrimidine Compounds As Pi3K Inhibitors
参考文献:China]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; Rt; 1 H,Rt
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106447-97-6 = 944401-56-3
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标题:High Selectivity Substituted Pyrimidine Pi3K Inhibitor
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; Rt; 6 H,Rt
标题:Quinazolines And Azaquinazolines As Dual Inhibitors Of Ras/raf/mek/erk And Pi3K/akt/pten/mtor Pathways And Their Preparation
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; Rt
标题:Design,Synthesis And Antiproliferative Activity Evaluation Of A Series Of Pyrrolo[2,1-F][1,2,4]Triazine Derivatives
作者:Xiang,Hao-Yue; Chen,Yan-Hong; Wang,Yi; Zhang,Xi; Ding,Jian; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2020 卷标:30(12)]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Tetrahydrofuran; 0 °C; 0.5 H,0 °C -> Rt1.2 Reagents: Sodium Thiosulfate Solvents: Water; Rt
标题:Preparation Of Pyrimidine Derivatives As Pi3K Inhibitors
参考文献:China]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 2 H,Rt
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作者:Peng,Wei; Tu,Zheng-Chao; Long,Zi-Jie; Liu,Quentin; Lu,Gui
参考文献:European Journal Of Medicinal Chemistry 日期:2016 卷标:108 页码:644-654]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 2 H,Rt
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106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 2 H,Rt
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作者:Burger,Matthew T.; Pecchi,Sabina; Wagman,Allan; Ni,Zhi-Jie; Knapp,Mark; Et Al
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106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 2 H,Rt
标题:Pyridine Derivatives As Pi3K Inhibitors And Their Preparation,Pharmaceutical Compositions And Use In The Treatment Of Diseases
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Chloroform; 0 °C; 3 H,Rt
标题:Preparation Of Triazine Compounds As Kinase Inhibitors For Treating Pi3K/mtor Pathway Related Disorders
参考文献:World Intellectual Property Organization]

106447-97-6 = 944401-56-3
反应条件:1.1 Reagents: N-Bromosuccinimide Solvents: Dichloromethane; 2 H,Rt
标题:Preparation Of Pyrrolone Derivatives As Herbicides
参考文献:World Intellectual Property Organization

2-氨基-4-三氟甲基吡啶置于n-溴代丁二酰亚胺(Nbs)体系中,用二氯甲烷作为反应溶剂,以87.96%的收率获得产物5-溴-4-(三氟甲基)吡啶-2-胺
参考文献:一系列吡咯并[2,1-F] [1,2,4]三嗪衍生物的设计,合成和抗增殖活性评估.
标题:一系列吡咯并[2,1-F] [1,2,4]三嗪衍生物的设计,合成和抗增殖活性评估.
摘要:通过支架跳跃策略设计了一系列6-氨基羰基吡咯并[2,1-F] [1,2,4]三嗪衍生物.测量化合物14A对pi3K的ic 50值,显示对p110α和p110δ的选择性活性,Ic 50分别为122 Nm和119 Nm.通过srb测定法评估所有合成的化合物对人癌细胞的抗增殖活性.化合物14A,14P和14Q对五种类型的人类癌细胞显示出有效的抗增殖活性,在此还研究了14Q的pk特性.
DOI:10.1016/j.Bmcl.2020.127194