CAS: 84031-17-4; Metaclazepam

该化合物是一种经过结构改造的苯二氮杂卓衍生物,在7位和5位分别使用一种溴替代物,在2位和1位分别使用一种溴代二苯组和2-氯苯组.甲基氧基甲基和甲基组有助于其独特的药理学特征.这一化合物对医药化学研究很感兴趣,因为它有可能成为合成新颖的苯二氮杂卓类的前体,并具有有针对性的结合性和选择性.其明确界定的结构有助于进行精确的修改,从而对研究...

结构式图片

MSDS等安全信息

    上下游产品

    5-(2-Chlorphenyl)-2,3-Dihydro-2-(Methoxymethyl)-1-Methyl-1H-1,4-Benzodiazepin 103380-39-8
    7-Bromo-1-Methyl-2-Chloromethyl-5-(2'-Chlorophenyl)-2,3-Dihydro-1H-1,4-Benzodiazepine 61677-61-0

    合成工艺路线路线简述

    • 合成目标产物 Metaclazepam 主要起始原料 1H-1,4-Benzodiazepine, 5-(2-Chlorophenyl)-2,3-Dihydro-2-(Methoxymethyl)-1-Methyl-
    • (文献来源)合成步骤主要原料 1H-1,4-Benzodiazepine, 5-(2-Chlorophenyl)-2,3-Dihydro-2-(Methoxymethyl)-1-Methyl-
    📜2-Chloro-N-[3-(N-Methylanilino)Propyl]Benzamide 反应生成 7-溴-5-(2-氯苯基)-2,3-二氢-2-(甲氧基甲基)-1-甲基-1H-1,4-苯并二氮杂卓
    参考文献:Roemer,D.;Ruhland,M.;Zeugner,H.;Milkowski,W.;Liepmann,H.
    标题:Roemer,D.;Ruhland,M.;Zeugner,H.;Milkowski,W.;Liepmann,H.

    海关参考信息

    专利信息


    专利号:US-2022233673-A1
    优先权日:2019-06-04
    标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF
    发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M
    权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND
    摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.

    专利号:SA-115360678-B1
    优先权日:2012-07-03
    标 题:Synthesis of 2-(5-bromo-4-(4-cyclopropylnaphthalene-1-yl)-4H-1,2,4-Trazol-3-ylthio)acetic acid

    专利号:ES-2763815-T3
    优先权日:2010-05-11
    标题 :Compositions, methods and systems for the synthesis and use of imaging agents

    专利号:CN-103910643-B
    优先权日:2014-04-23
    标 题:A kind of anticancer active ketone derivative, its synthesis method and its application

    专利号:CN-103910643-A
    优先权日:2014-04-23
    标题:A kind of anticancer active ketone derivative, its synthesis method and its use

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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1007/s00216-011-5187-9
    摘要:Remane D, Meyer MR, Wissenbach DK, Maurer HH. Ultra high performance liquid chromatographic-tandem mass spectrometric multi-analyte procedure for target screening and quantification in human blood plasma: validation and application for 31 neuroleptics, 28 benzodiazepines, and Z-drugs. Analytical and Bioanalytical Chemistry. 2011 Jul 21;401(4):1341. doi: 10.1007/s00216-011-5187-9.
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