专利号:US-2022233673-A1 优先权日:2019-06-04 标 题:METHODS OF PRODUCING SHIGA TOXIN B-SUBUNIT (STxB) MONOMERS AND OLIGOMERS, AND USES THEREOF 发明人:BILLET ANNE; SCHMIDT FRÉDÉRIC; JOHANNES LUDGER; SERVENT DENIS; MOURIER GILLES; TARTOUR ÉRIC; KAY MICHAEL; FULCHER JAMES M 权利人:INST CURIE; CENTRE NAT RECH SCIENT; INST NAT SANTE RECH MED; COMMISSARIAT A LENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES CEA; APHP ASSIST PUBLIQUE HOPITAUX DE PARIS; UNIV PARIS; UNIV OF UTAH RESEARCH FOUDATION; UNIV UTAH RES FOUND 摘要:A method of producing a monomer of a Shiga toxin B-subunit (STxB) protein or of a variant thereof by peptide chemical synthesis, as well as to a method of producing a pentamer of the STxB protein or of the variant thereof. The methods are particularly advantageous as they overcome major issues typically observed in peptide chemical synthesis, including solubility and purity issues.
专利号:SA-115360678-B1 优先权日:2012-07-03 标 题:Synthesis of 2-(5-bromo-4-(4-cyclopropylnaphthalene-1-yl)-4H-1,2,4-Trazol-3-ylthio)acetic acid
专利号:ES-2763815-T3 优先权日:2010-05-11 标题 :Compositions, methods and systems for the synthesis and use of imaging agents
专利号:CN-103910643-B 优先权日:2014-04-23 标 题:A kind of anticancer active ketone derivative, its synthesis method and its application
专利号:CN-103910643-A 优先权日:2014-04-23 标题:A kind of anticancer active ketone derivative, its synthesis method and its use
参考文献:10.1007/s00216-011-5187-9 摘要:Remane D, Meyer MR, Wissenbach DK, Maurer HH. Ultra high performance liquid chromatographic-tandem mass spectrometric multi-analyte procedure for target screening and quantification in human blood plasma: validation and application for 31 neuroleptics, 28 benzodiazepines, and Z-drugs. Analytical and Bioanalytical Chemistry. 2011 Jul 21;401(4):1341. doi: 10.1007/s00216-011-5187-9.